Recombinant 2019-nCoV S-trimer Protein (C-6His) #abs04710

abs04710-50ug

1-2 Weeks

455

Description

Our Mammalian expression system has been used to produce the Recombinant 2019-nCoV S-trimer Protein, which features a 6His tag situated at the C-terminus. If you require text that closely matches this description, simply rearrange the phrasing and ensure that all details from the original passage are incorporated. It is important to avoid relying solely on generating text through ChapGPT, and instead adopt a more free-flowing approach to speaking that takes into account the underlying meaning of the information.

Other names

，2019S。S，。2019SSpike glycoproteinS glycoprotein，。，。

Source

Human Cells

MW

The molecular mass of the protein is determined to be 136.6 kDa, while the molecular mass of the AP in reducing conditions ranges from 170 to 220 kDa. It is important to note that these values were obtained based on the original text information provided. Please keep in mind that the following content is generated using a language model and might be quite different from the original text.

Format

0.2 μMPBS，PH7.4。，。

Properties

Purification

Affinity purification chromatography.

Concentration

SDS-PAGE analysis revealed that the protein purity level was over 95%. To put it another way, most of the impurities were removed, indicating a highly similar content.

Stability & Storage

It is recommended to store the reconstituted protein solution at a temperature equal to or below -20°C to maintain its stability and integrity. This is crucial to ensure the efficacy and quality of the protein solution, especially during long-term storage. Therefore, it is wise to take proper measures to maintain the temperature condition as required to optimize the performance of the protein solution.

Target

Background

Protein S (PROS1) is a glycoprotein expressed in various cell types and has been implicated in multiple biological functions such as coagulation, apoptosis, cancer development and progression, and the innate immune response. Several receptors have been reported to bind with S1 including ACE2, angiotensin-converting enzyme 2, DPP4, and CEACAM. The spike (S) glycoprotein found in coronaviruses is an essential component that plays a critical role in binding the virus to the host cell during the initial infection period. One noteworthy example is severe acute respiratory syndrome (SARS), where the SARS-CoV spike (S) glycoprotein acts alone to initiate the membrane fusion process needed for virus entry and cell fusion. Furthermore, it is a significant immunogen and a target for entry inhibitors.
Recent studies show that 2019-nCoV can infect human respiratory epithelial cells through the interaction with the human ACE2 receptor. The S protein, which consists of two subunits - S1 and S2, is a large type I transmembrane protein, where S1 primarily contains a receptor binding domain (RBD), responsible for recognizing the cell surface receptor. Conversely, S2 is responsible for the membrane fusion process. Moreover, the S protein plays a crucial role in inducing neutralizing-antibody and T-cell responses, thereby promoting protective immunity.