Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-YB1 Polyclonal Antibody#abs133302

Please be informed that the provided price is for your reference only. For detailed pricing information, please get in touch with our seller, Vecent. Kindly note that the generated content should not be based on the original text information, but rather be entirely different in style and tone....

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs133302-100ug	1-2 Weeks	301.0
abs133302-50ug	1-2 Weeks	201.0

Overview
catalog	abs133302
Other names	- CBF-A, also known as CCAAT binding transcription factor I subunit A or CCAAT-binding transcription factor I subunit A, is a crucial DNA binding protein in various cellular processes. It is also referred to as CSDA2, CSDB, DBPB, or DNA-binding protein B. - Additionally, CBF-A is sometimes called EFI-A or Enhancer factor I subunit A. It is also identified by other names such as MDR NF1, MGC104858, MGC110976, MGC117250, NSEP 1, or Nuclease sensitive element binding protein 1. - Subunit A of CBF-A is responsible for binding to specific DNA sequences and regulating gene expression. It plays a significant role in various cellular functions and can interact with other proteins to form complex regulatory networks. - Another name for CBF-A is Y-box binding protein 1 or Y-box transcription factor. It is involved in the regulation of gene transcription, translation, and DNA repair. YB-1, YB 1, or YBOX1_HUMAN are alternative names used for CBF-A. - The diverse range of functions attributed to CBF-A highlights its importance in cellular processes and its potential as a therapeutic target for various diseases. Further research is necessary to fully understand its mechanisms and potential applications in medicine.
Source	Rabbit
Specificity	The YB1 Antibody is able to detect total YB1 protein levels that are naturally occurring within an organism. This information is important in the understanding of various biological processes and functions that involve YB1. By detecting endogenous levels of YB1, this antibody provides researchers with a valuable tool to study this protein.
Species Reactivity	Human;Mouse;Rat
Antigen	YB1
Application	WB 1:1000-3000、IHC 1:200、ICC/IFELISA(peptide) 1:20000-1:40000。WB 1:1000-3000Western blot，1:10001:3000；IHC 1:200，1:200；ICC/IF，；ELISA(peptide) 1:20000-1:40000，1:200001:40000。，，。
Immunogen	A synthesized peptide derived from human YB1.
MW	50kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for the purification of the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Ensure the storage temperature is maintained at -20 °C for a duration of one year, without subjecting the product to multiple freeze/thaw cycles.
Storage buffer	This solution contains Rabbit IgG in a buffer of phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. This solution should be stored at -20°C and is stable for 12 months from the date of receipt. Please ensure proper storage and handling to maintain the quality of the product.
Target
Background	Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro.
Posttranslational modification	Ubiquitinated by RBBP6; leading to a decrease of YBX1 transcactivational ability.In the absence of phosphorylation the protein is retained in the cytoplasm.Cleaved by a 20S proteasomal protease in response to agents that damage DNA. Cleavage takes place in the absence of ubiquitination and ATP. The resulting N-terminal fragment accumulates in the nucleus (By similarity).
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;
UniPort	P67809