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Rabbit Anti-U2AF1 Polyclonal Antibody#abs135715

Description

Catalog-specification	Delivery time	USD price
abs135715-100ug	1-2 Weeks	301.0
abs135715-50ug	1-2 Weeks	201.0

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Overview
catalog	abs135715
Description	The U2 auxiliary factor (U2AF) is composed of a small and a large subunit and is an essential protein for the binding of U2 snRNP to the branch site on pre-mRNA. U2AF1, also known as RN, FP793, U2AF35, U2AFBP, RNU2AF1, is the small subunit responsible for facilitating interactions between the large subunit and enhancer-bound proteins, thus playing a crucial role in both constitutive and enhancer-dependent RNA splicing. The U2AF1 gene is situated on chromosome 21q22.3, which is a critical region associated with three diseases: progressive myoclonus epilepsy, autoimmune polyglandular disease type 1, and a particular form of bipolar affective disorder. To generate highly similar content, the original information is rearranged to provide a different presentation while retaining the core message.
Other names	U21（U2AF1），U235。RNU2AF1，。U2，。U235，U235。U2(RNU2)，U2(RNU2)。，U2AF1U2AF1_HUMAN。U2，。
Source	Rabbit
Specificity	The U2AF1 antibody has been designed to detect total U2AF1 protein levels in the body's natural state. By targeting the endogenous levels of this protein, the antibody provides a reliable means of monitoring U2AF1 expression in various biological samples. Whether used for research or diagnostic purposes, this tool is an essential part of studying the physiological functions and pathological implications of U2AF1 protein. With its accurate and specific detection capabilities, the U2AF1 antibody is an invaluable resource for scientists and clinicians working in a variety of fields.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Bovine;Chicken;Xenopus
Antigen	U2AF1
Application	The dilution ratios for WB, IHC, and ELISA (peptide) are as follows: WB – 1:500 to 1:2000, IHC – 1:50 to 1:200, and ELISA (peptide) – 1:20,000 to 1:40,000. Please note that the information provided is based on the original text.
Immunogen	A synthesized peptide derived from human U2AF1.
MW	28kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLinkâ„¢ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 Â°C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 Â°C.Stable for 12 months from date of receipt.
Target
Background	Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.
Celluar localization	Nucleus;
UniPort	Q01081