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Rabbit Anti-SCNN1D Polyclonal Antibody#abs140844

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Description

Catalog-specification	Delivery time	USD price
abs140844-100ug	1-2 Weeks	301.0
abs140844-50ug	1-2 Weeks	201.0

Overview
catalog	abs140844
Other names	The Amiloride-sensitive sodium channel subunit delta, also known as ENaC Delta or DNACH, is a crucial component of the Epithelial Na(+) channel. This nonvoltage-gated sodium channel 1 subunit delta is mainly found in the kidney and lungs, acting as a regulator of sodium and water reabsorption. The SCCN1D gene encodes the Delta-ENaC protein, consisting of two transmembrane domains and a large extracellular loop. Variations in this gene have been associated with hypertension and lung diseases, such as cystic fibrosis and bronchiectasis. Understanding the function and regulation of ENaC Delta can have significant implications for the treatment and management of these conditions.
Source	Rabbit
Specificity	The total SCNN1D levels in the body can be detected using the SCNN1D Antibody, which is capable of identifying endogenous levels. A similar piece of content can be created by rearranging the original text information and ensuring that the generated content is based on the same information.
Species Reactivity	Human;Mouse
Antigen	SCNN1D
Application	WB1:500~1:1000，/1:100-1:500，（），1:20000-1:40000。。
Immunogen	A synthesized peptide.
MW	70 KD
Properties
Concentration	1mg/ml
purification	Through the application of peptide affinity chromatography utilizing SulfoLink™ Coupling Resin, our team was able to successfully purify the antiserum. This process was key in obtaining a high-quality final product.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing, as this can significantly compromise its stability and efficacy. Ensuring proper storage conditions will help maintain the integrity of the product and ensure its effectiveness over time, so it is important to follow these guidelines closely.
Storage buffer	The Rabbit IgG is stored in a solution of phosphate buffered saline at a pH of 7.4, with 150mM NaCl, and 0.02% sodium azide, and 50% glycerol, and should be kept at a temperature of -20°C. This solution can remain stable for up to 12 months from the date of its receipt.
Target
Background	Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Celluar localization	Cytoskeleton;Plasma Membrane;
UniPort	P51172