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Rabbit Anti-SH2B3 Polyclonal Antibody#abs139418

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Description

Catalog-specification	Delivery time	USD price
abs139418-100ug	1-2 Weeks	301.0
abs139418-50ug	1-2 Weeks	201.0

Overview
catalog	abs139418
Other names	Lnk, also known as Lymphocyte Adapter Protein or Lymphocyte Specific Adapter Protein, is an important protein involved in signal transduction pathways. It plays a crucial role in regulating lymphocyte development and function. Lnk is encoded by the SH2B3 gene and is commonly referred to as SH2B Adapter Protein 3. The Lnk protein is specifically expressed in lymphocytes, which are a type of white blood cells involved in immune responses. It acts as an adaptor protein, connecting various signaling molecules and pathways to regulate lymphocyte activation, proliferation, and differentiation. The function of Lnk is mediated through its SH2 domains, which enable it to bind to specific phosphotyrosine residues in target proteins. By interacting with these target proteins, Lnk can positively or negatively regulate their activity, thereby fine-tuning the signaling events in lymphocytes. Studies have shown that Lnk deficiency in mice leads to enhanced lymphocyte proliferation and activation, resulting in autoimmune disorders and increased susceptibility to infections. On the other hand, overexpression of Lnk has been associated with impaired lymphocyte function and compromised immune responses. Understanding the role of Lnk and its signaling pathways is crucial for gaining insights into lymphocyte biology and immune system regulation. Further research on Lnk may provide potential therapeutic targets for immune-related disorders and diseases.
Source	Rabbit
Specificity	The total SH2B3 levels can be detected using the SH2B3 Antibody, which specifically targets the endogenous levels of SH2B3 protein.
Species Reactivity	Human
Antigen	SH2B3
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human SH2B3.
MW	63 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was achieved through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	This product is Rabbit IgG preserved in phosphate-buffered saline with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C. The product remains stable for a period of 12 months from the date of receipt.
Target
Background	Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
Tissue specificity	Preferentially expressed by lymphoid cell lines.
Posttranslational modification	Tyrosine phosphorylated by LCK.
Celluar localization	Cytosol;
UniPort	Q9UQQ2