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Rabbit Anti-LAMB3 Polyclonal Antibody#abs132760

Please note that the price mentioned is only for your reference. To obtain the specific pricing details, kindly get in touch with our seller, Vecent. Western blot analysis of LAMB3 expression in HEK293 cells ,The lane on the left is treated with the antigen-specific peptide. This product is for...

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Description

Catalog-specification	Delivery time	USD price
abs132760-100ug	1-2 Weeks	301.0
abs132760-50ug	1-2 Weeks	201.0

Please note that the price mentioned is only for your reference. To obtain the specific pricing details, kindly get in touch with our seller, Vecent.

Overview
catalog	abs132760
Description	During embryonic development, cells are believed to attach, migrate, and organize into tissues with the help of a high affinity receptor called laminin. This receptor plays a crucial role in mediating the interaction between cells and other components of the extracellular matrix. Its strong binding ability allows for efficient attachment of cells to their surroundings, facilitating migration and ultimately contributing to the overall organization of tissues.
Other names	Laminin is a protein that plays a crucial role in the structure and function of various tissues in the body. One of its subunits, called beta-3, is encoded by the LAMB3 gene. It is also known by other names such as BM600 125KDA, Epiligrin subunit beta, FLJ99565, Kalinin B1 chain, Kalinin subunit beta, LAM5, LAMB3_HUMAN, Laminin B1k chain, Laminin-5 subunit beta, LAMNB1, and Nicein subunit beta. The presence of Laminin beta-3 is essential for the formation and stability of Laminin-5, which is involved in cell adhesion and migration. It is crucial for the integrity of the skin, as mutations in the LAMB3 gene can cause a severe skin disorder called Herlitz junctional epidermolysis bullosa. Understanding the function and structure of Laminin subunit beta-3 is crucial for studying and treating various diseases and conditions related to cell adhesion, migration, and tissue integrity. Further research in this area may provide insights into potential therapeutic targets for such conditions.
Source	Rabbit
Specificity	The LAMB3 antibody is capable of detecting the total endogenous levels of LAMB3. To create similar content, one could say that the LAMB3 antibody is able to identify and measure the amount of LAMB3 present within an organism, allowing for comprehensive analysis and understanding of LAMB3 activity.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Sheep;Dog;Bovine;
Antigen	LAMB3
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	130 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is advisable to store it at a temperature of -20 °C for a duration of one year. It is important to prevent any repeated cycles of freezing and thawing. This will help preserve the product and prevent any degradation from occurring. Therefore, it is recommended to handle the product carefully and follow the storage instructions accordingly.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Tissue specificity	Found in the basement membranes (major component).
Celluar localization	Extracellular region or secreted;
UniPort	Q13751