Rabbit Anti-GADD45B Polyclonal Antibody#abs132754
Please be advised that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent. Our team will be more than happy to assist you. Western blot analysis of GADD45B expression in Jurkat cell lysate; Fetal liver cell lysate;...
Description
| Catalog-specification | Delivery time | USD price |
abs132754-100ug | 1-2 Weeks | 301.0 |
abs132754-50ug | 1-2 Weeks | 201.0 |
Please be advised that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent. Our team will be more than happy to assist you.
| Overview | |
catalog | abs132754 |
Description | Its role encompasses the regulation of both growth and apoptosis processes, as it is directly involved in these regulatory mechanisms. Additionally, it plays a crucial role in activating the stress-responsive MTK1/MEKK4 MAPKKK pathway. |
| Other names | GADD45 Beta, also known as Gadd45b or GADD45BETA, is a protein that plays a role in growth arrest and DNA damage response. It is encoded by the growth arrest and DNA damage-inducible gene GADD45B and is a homolog of the mouse protein MYD118. GADD45 Beta is involved in negative growth regulation and is a primary response gene in myeloid differentiation. Its function is to respond to DNA damage and halt cell growth. The protein is a key player in maintaining genomic stability and preventing the progression of cancer by inducing cell cycle arrest and promoting DNA repair pathways. GADD45 Beta is an important factor in cellular stress responses and is implicated in various biological processes, including cell proliferation, apoptosis, and differentiation. Its dysregulation has been linked to the development and progression of several human diseases, making it a potential target for therapeutic interventions. |
| Source | Rabbit |
| Specificity | The GADD45B antibody is capable of detecting the overall levels of GADD45B that are present endogenously. A highly similar content can be generated by rearranging the given information, while ensuring that the content remains based on the original text. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Pig;Sheep;Dog;Bovine;Horse |
| Antigen | GADD45B |
| Application | WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | A synthesized peptide. |
| MW | 18 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification. The resultant product is highly purified and of superior quality. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Target | |
Background | Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. |
| Celluar localization | Nucleus; |
| UniPort | O75293 |
Western blot analysis of GADD45B expression in Jurkat cell lysate; Fetal liver cell lysate; Fetal heart cell lysate; A549 cell lysate,The lane on the left is treated with the antigen-specific peptide.
This product is for research use only, not for use in diagnostic prodecures or in human.
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