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Rabbit Anti-GADD45A Polyclonal Antibody#abs132753

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Description

Catalog-specification	Delivery time	USD price
abs132753-50ug	1-2 Weeks	201.0
abs132753-100ug	1-2 Weeks	301.0

Overview
catalog	abs132753
Other names	The protein known as DDIT-1, or DNA damage-inducible transcript 1, is also referred to as GADD45 alpha, or Growth arrest and DNA damage-inducible protein GADD45 alpha. It is a highly important molecule involved in the response to DNA damage in humans. Its gene is called DDIT1 and it codes for the protein that is involved in coordinating cellular repair mechanisms when DNA damage occurs. DDIT-1 is crucial for ensuring the proper functioning of various cellular processes and maintaining genomic integrity. Additionally, it plays a role in regulating cell growth and proliferation, making it an important target for potential cancer therapies. The study of DDIT-1 and its function continues to be an active area of research in molecular biology.
Source	Rabbit
Specificity	The antibody against GADD45A is designed to recognize the total amount of endogenous GADD45A present in the sample. This ensures accurate detection and measurement of the protein without interference from other molecules. By using this antibody, researchers can obtain reliable results and gain insights into the biological processes in which GADD45A is involved.
Species Reactivity	Human;Mouse
Antigen	GADD45A
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	26 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. The resulting content, although rephrased, accurately conveys the same information as the original text.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal preservation, it is recommended to store the item at a temperature of -20 °C for a period of one year. It is important to avoid exposing the item to repeated freeze/thaw cycles, as this can compromise its integrity.
Storage buffer	The solution of Rabbit IgG is made up of phosphate buffered saline with a pH level of 7.4, 150mM NaCl, 0.02% of sodium azide, and 50% glycerol. This formulation ensures optimal conditions for preservation and storage of the protein.
Target
Background	In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
Tissue specificity	By UV irradiation, X-rays, growth arrest and alkylating agents. The induction is mediated by some kinase(s) other than PKC.
Celluar localization	Nucleus;
UniPort	P24522