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Rabbit Anti-TSC-22R Polyclonal Antibody#abs139597

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Description

Catalog-specification	Delivery time	USD price
abs139597-100ug	1-2 Weeks	301.0
abs139597-50ug	1-2 Weeks	201.0

Overview
catalog	abs139597
Other names	The Delta sleep-inducing peptide immunoreactor, also known as DIP or DSIP, is a protein that has been found to induce delta sleep in laboratory animals. It is also known as DSIP-immunoreactive leucine zipper protein, Dsip1, Dsipi, GILZ (Glucocorticoid-induced leucine zipper protein), hDIP, Protein DIP, T22D3_HUMAN, TSC-22-like protein, TSC-22-related protein, TSC-22R, TSC22 domain family protein 3, TSC22 domain family member 3, TSC22 related inducible leucine zipper 3, and TSC22D3. The DSIP immunoreactive peptide has been extensively studied for its potential use in treating sleep disorders. Its ability to trigger delta sleep has been found to be useful in the treatment of various sleep disorders, including insomnia. Researchers have also been exploring its use in other medical fields, such as cancer research, as it has shown anti-cancer properties in various studies. TSC22D3 is the official gene name of the protein, which is a member of the TSC22 domain family of leucine zipper transcription factors. These proteins are known to regulate gene expression and play a crucial role in various biological processes, including cell proliferation, differentiation, and apoptosis. TSC22D3 is also found to play a role in modulating the immune system response. Overall, the DSIP immunoreactor is a promising candidate for further research and development in the field of sleep medicine and potentially other medical fields. Its ability to induce delta sleep and the growing understanding of its biological functions make it an area of active research interest.
Source	Rabbit
Specificity	The TSC-22R Antibody identifies the total amount of TSC-22R present in the body. It is capable of detecting endogenous levels of this protein.
Species Reactivity	Human
Antigen	TSC-22R
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human TSC-22R.
MW	15 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was purified through peptide affinity chromatography. To ensure high-quality purification, this method was employed to remove impurities and increase the overall purity of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	For a period of twelve months, it is recommended that the item be kept at a temperature of -20 °C. It is important to avoid exposing the item to repeated cycles of freezing and thawing.
Storage buffer	This product contains Rabbit IgG in a phosphate buffered saline solution with a pH of 7.4, 150mM NaCl, and 0.02% sodium azide. It also has 50% glycerol added, and should be stored at -20 °C for best results. Please be advised that this product is stable for 12 months from the date of receipt, so be sure to take note of this information when planning your use of it.
Target
Background	Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).
Tissue specificity	Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells.
Celluar localization	Cytosol;Nucleus;
UniPort	Q99576