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Rabbit Anti-HIPK3 Polyclonal Antibody#abs139599

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Description

Catalog-specification	Delivery time	USD price
abs139599-100ug	1-2 Weeks	301.0
abs139599-50ug	1-2 Weeks	201.0

Overview
catalog	abs139599
Other names	Here are a few possible ways to rearrange and rephrase the given content: 1. ANPK, also known as androgen receptor-interacting nuclear protein kinase, is a serine/threonine-protein kinase that interacts with the androgen receptor in the nucleus. ANPK is also called Fas-interacting serine/threonine-protein kinase (FIST) or homeodomain-interacting protein kinase 3 (Hipk3). It is homologous to protein kinase YAK1 and is encoded by the RP24 297H17.5 gene in humans. 2. DYRK6, or dual-specificity tyrosine phosphorylation-regulated kinase 6, is a nuclear protein kinase that interacts with the androgen receptor and other transcription factors. DYRK6 is also known as Fas-interacting serine/threonine-protein kinase 3 (FIST3) or homeodomain-interacting protein kinase 3 (Hipk3). Its homolog in yeast is called protein kinase YAK1 (PKY). RP24 297H17.5 is the gene that encodes DYRK6 in humans. 3. FIST, or Fas-interacting serine/threonine-protein kinase, is a multifunctional kinase that plays a role in apoptosis, transcriptional regulation, and chromatin remodeling. FIST is also called ANPK (androgen receptor-interacting nuclear protein kinase) or homeodomain-interacting protein kinase 3 (Hipk3). It is homologous to the yeast protein kinase YAK1 (PKY) and is encoded by the RP24 297H17.5 gene in humans. 4. HIPK3, or homeodomain-interacting protein kinase 3, is a nuclear kinase that interacts with transcription factors such as the androgen receptor and p53. HIPK3 is also known as ANPK (androgen receptor-interacting nuclear protein kinase) or Fas-interacting serine/threonine-protein kinase (FIST). Its homolog in yeast is protein kinase YAK1 (PKY) and its human gene is RP24 297H17.5. 5. YAK1, or yeast-associated kinase 1, is a protein kinase that is conserved from yeast to humans. Its homolog in humans is DYRK6 (dual-specificity tyrosine phosphorylation-regulated kinase 6), which is also called ANPK (androgen receptor-interacting nuclear protein kinase), FIST3 (Fas-interacting serine/threonine-protein kinase 3), or HIPK3 (homeodomain-interacting protein kinase 3). RP24 297H17.5 is the gene that encodes DYRK6/HIPK3/FIST3/ANPK in humans.
Source	Rabbit
Specificity	The HIPK3 Antibody is designed to detect the total amount of HIPK3 at its endogenous levels. This means that the antibody is capable of identifying and binding to HIPK3 protein present within the natural state of the cellular system. The detection can be useful for determining the expression and localization of HIPK3 within the cells.
Species Reactivity	Human
Predictive reaction species	Pig;Chicken;Sheep;Dog;Bovine
Antigen	HIPK3
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human HIPK3.
MW	134 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, peptide affinity chromatography was utilized to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality, keep the store temperature at -20 °C for one year, and make sure you do not subject it to repeated freeze/thaw cycles. Make sure to follow these instructions to maintain the product's integrity.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Tissue specificity	Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.
Posttranslational modification	Autophosphorylated, but autophosphorylation is not required for catalytic activity.May be sumoylated.
Celluar localization	Cytosol;Nucleus;
UniPort	Q9H422