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Rabbit Anti-SS2R Polyclonal Antibody#abs133156

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Description

Catalog-specification	Delivery time	USD price
abs133156-100ug	1-2 Weeks	301.0
abs133156-50ug	1-2 Weeks	201.0

Overview
catalog	abs133156
Description	The receptor responsible for the recognition of somatostatins-14 and -28 is linked to the inhibition of adenylyl cyclase through pertussis toxin sensitive G proteins. Furthermore, this receptor stimulates phosphotyrosine phosphatase and PLC via both pertussis toxin sensitive and insensitive G proteins. In RIN-5F cells, the receptor suppresses voltage dependent calcium-channels, thereby inhibiting calcium entry.
Other names	SST2, also known as somatostatin receptor type 2 or SS-2-R, is encoded by the SRIF-1 gene, also called SRIF1 or SS2R. It is an important receptor involved in the binding of somatostatin. SST2, or SS2R, is one of the subtypes of somatostatin receptors and is found in humans.
Source	Rabbit
Specificity	The levels of total SS2R can be accurately detected by the SS2R antibody, which specifically targets endogenous SS2R.
Species Reactivity	Human;Mouse;Rat
Antigen	SS2R
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	55 kDa;Exposure time : 6 minutes
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography utilizing SulfoLink™ Coupling Resin was employed to purify the antiserum. Let's rearrange the content and ensure that the generated content is based on the original information.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure preservation, it is recommended to store the item at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to multiple freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
Tissue specificity	Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.
Posttranslational modification	Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization (By similarity).
Celluar localization	Cytosol;Plasma Membrane;
UniPort	P30874