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Rabbit Anti-CIRBP Polyclonal Antibody#abs133022

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Description

Catalog-specification	Delivery time	USD price
abs133022-100ug	1-2 Weeks	301.0
abs133022-50ug	1-2 Weeks	201.0

Overview
catalog	abs133022
Description	This mRNA binding protein is known as a cold-inducible factor that plays a crucial role in protecting cells from genotoxic stress. It achieves this by stabilizing the mRNA transcripts of various genes involved in promoting cell survival. Acting as a translational activator, it facilitates the translation of these transcripts into functional proteins. Interestingly, it also contributes to the control of cell proliferation during cold exposure, acting as an essential component in the suppression of cell division. By binding specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts like RPA2 and TXN, it functions as a translational repressor, limiting their translation into proteins. Furthermore, it exhibits the ability to promote the formation of stress granules, specialized cellular structures that facilitate the response to stress, when overexpressed. Thus, this protein possesses multiple functions that collectively aid in the cellular stress response and maintenance of cell viability.
Other names	A18 hnRNP, also known as A18HNRNP, is a protein called cirbp or CIRBP_HUMAN in scientific terms. It is commonly referred to as Cold inducible RNA binding protein or Cold-inducible RNA-binding protein. Another name for this protein is Glycine rich RNA binding protein or Glycine-rich RNA-binding protein CIRP. Additionally, it is sometimes called testicular tissue protein Li 39. These different names refer to the same protein. To further elaborate, this protein, CIRBP_HUMAN, has a significant role in responding to cold temperatures. It binds with RNA molecules in the cells and acts as a regulator of gene expression. The protein contains a high percentage of glycine amino acids, hence the name Glycine rich RNA binding protein. Its expression is induced when the body is exposed to cold conditions, hence the name Cold-inducible RNA-binding protein. The protein A18 hnRNP, or CIRBP_HUMAN, is of particular interest due to its involvement in various physiological processes. It has been extensively studied in the context of cold tolerance and thermoregulation in mammals. Its functions are not limited to responding to cold stress but also extend to other cellular processes. In conclusion, A18 hnRNP, also referred to as A18HNRNP, cirbp, CIRBP_HUMAN, CIRP, Cold inducible RNA binding protein, Cold-inducible RNA-binding protein, Glycine rich RNA binding protein, Glycine-rich RNA-binding protein CIRP, and testicular tissue protein Li 39, is a highly versatile protein involved in RNA binding and gene expression regulation, particularly in response to cold temperatures.
Source	Rabbit
Specificity	The CIRBP antibody is capable of detecting total CIRBP levels that are naturally present within the system. To rephrase this information, the antibody is designed to identify the endogenous expression of CIRBP molecules.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus
Antigen	CIRBP
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	18 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum. Let me provide you with a similar content that maintains the context but is rephrased.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
Tissue specificity	Ubiquitous.
Posttranslational modification	Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity).Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation.
Celluar localization	Nucleus;
UniPort	Q14011