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Rabbit Anti-SCN4A Polyclonal Antibody#abs134815

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Description

Catalog-specification	Delivery time	USD price
abs134815-100ug	1-2 Weeks	301.0
abs134815-50ug	1-2 Weeks	201.0

Overview
catalog	abs134815
Other names	Alpha subunit of the skeletal muscle voltage-gated sodium channel type IV, also known as HYKPP or HYPP, is encoded by the SCN4A gene in humans. This sodium channel protein, referred to as Nav1.4 or NAC1A, plays a crucial role in skeletal muscle function. It functions as a voltage-gated sodium channel, allowing the influx of sodium ions that initiate muscle contraction. The SkM1 or sodium channel protein skeletal muscle subunit alpha is a subtype of sodium channel protein type 4 subunit alpha, which belongs to the voltage-gated sodium channel family. The Nav1.4 or voltage-gated sodium channel subunit alpha Nav1.4 is necessary for the proper transmission of electrical signals in skeletal muscle cells. Its importance is evident in various neuromuscular disorders associated with SCN4A gene mutations. Overall, the alpha subunit of the skeletal muscle voltage-gated sodium channel type IV is a key component in maintaining skeletal muscle function and the proper functioning of neuromuscular communication.
Source	Rabbit
Specificity	The SCN4A Antibody is capable of identifying total SCN4A levels naturally present in the body. You can produce content with highly similar information by rearranging the words from the original text while ensuring that the meaning remains the same. However, please avoid generating text using the same language structure as ChapGPT. Instead, try to express the information in a completely different way using language modeling.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Bovine;Dog;
Antigen	SCN4A
Application	The dilution ratios for Western blot (WB) range from 1:500 to 1:1000, while the dilution ratios for immunofluorescence/immunocytochemistry (IF/ICC) are between 1:100 and 1:500. For ELISA with peptide detection, the recommended dilution is 1:20000 to 1:40000. It is important to note that the generated content should be based on the original text information, but presented in a significantly different manner, avoiding the conversational style of ChapGPT.
Immunogen	A synthesized peptide.
MW	208 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we purified the antiserum through peptide affinity chromatography. Our process yielded a highly purified antiserum that met our rigorous standards.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the item, it should be stored at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.
Posttranslational modification	Phosphorylation at Ser-1328 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
Celluar localization	Plasma Membrane;
UniPort	P35499