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Rabbit Anti-Actin Alpha1 Polyclonal Antibody#abs131430

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Description

Catalog-specification	Delivery time	USD price
abs131430-100ug	1-2 Weeks	301.0
abs131430-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly reach out to our seller, Vecent. We would be happy to assist you further.

Overview
catalog	abs131430
Description	Actins, widely expressed in all eukaryotic cells, are crucial proteins for diverse forms of cell motility. They exhibit a remarkably conserved nature, playing significant roles in a variety of biological processes.
Other names	Actin is a protein that plays a crucial role in various cellular processes. It regulates muscle contraction and provides structural support to cells. There are several different forms of actin, including ACTA, ACTA1, ACTA2, ACTC, ACTC1, and others. ACTA is an abbreviation for "Actin" and can refer to any form of actin protein. ACTA1 specifically refers to alpha skeletal muscle actin, while ACTA2 refers to alpha-actin-2 found in smooth muscle cells. ACTC and ACTC1 denote cardiac muscle alpha actin 1 and skeletal muscle alpha actin 1, respectively. Additionally, there is a human gene called ACTS_HUMAN that encodes actin protein. ACTSA is the abbreviation for alpha 2 actin and represents another variant of actin. Overall, actin proteins are essential for cell structure and muscle function.
Source	Rabbit
Specificity	The detection of endogenous levels of total Actin α 1 can be achieved using the Actin α 1 Antibody. The antibody is specifically designed to recognize and bind to Actin α 1 protein in biological samples. This allows for the quantification and analysis of Actin α 1 levels in various experimental settings. By detecting and measuring the presence of Actin α 1, researchers can gain insights into its role and function in different cellular processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Bovine;Chicken;Rabbit
Antigen	Actin alpha1
Application	(ELISA)1:20000-1:40000，。(IHC)(IF/ICC)，1:50-1:2001:100-1:500。Western(WB)，1:500-1:2000。，(IP)。。
Immunogen	A peptide that has been synthesized using human Actin α 1 as its source is available. This peptide is highly similar to the original protein, as it has been created using the same amino acid sequence. With its unique structure and properties, this synthesized peptide is a valuable tool for research in various fields. It can be used for investigating the function of Actin α 1, as well as for developing new drugs and therapies with potential medical applications. Overall, this synthesized peptide represents an important innovation in the field of biochemistry and molecular biology.
MW	42 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was used to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal storage conditions, it is recommended to keep the product in a freezer at a temperature of -20 °C for a period of one year. It is crucial to avoid any freeze/thaw cycles that may occur, as this can negatively impact the quality of the product. Taking these precautions will ensure that the product remains stable and effective for an extended period of time.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Posttranslational modification	Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.(Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-52 of one monomer and Glu-272 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148).
Celluar localization	Cytoskeleton;Cytosol;Extracellular region or secreted;
UniPort	P68133

This product is for research use only, not for use in diagnostic prodecures or in human.

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