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Rabbit Anti-SHANK3 Polyclonal Antibody#abs139421

Please note that the price mentioned above is for your reference only. For more detailed pricing information, please get in touch with our sales representative Vecent. Western blot analysis SHANK3 using Jurkat whole cell lysates This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs139421-100ug	1-2 Weeks	301.0
abs139421-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is for your reference only. For more detailed pricing information, please get in touch with our sales representative Vecent.

Overview
catalog	abs139421
Other names	KIAA1650, also known as AI841104 or DEL22q13.3, is a gene that codes for the Proline-rich synapse-associated protein 2 (ProSAP2), also referred to as SH3 and multiple ankyrin repeat domains 3 (SHANK3). This protein is a crucial component of the postsynaptic density, playing an essential role in synaptic function. ProSAP2, or Shank3, is involved in regulating the formation and maintenance of synapses, which are the connections between nerve cells in the brain. It is composed of multiple protein domains, including SH3 and ankyrin repeat domains, which contribute to its diverse functions. The Shank3 protein is particularly abundant in the brain and is primarily located in the postsynaptic density, a specialized region of the neuronal synapse. It acts as a scaffold protein, linking various signaling molecules and receptors to maintain the structural and functional integrity of the synapse. Mutations or deletions in the SHANK3 gene have been associated with neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability. These genetic alterations disrupt normal synaptic function and can lead to impaired neuronal communication and cognitive deficits. Understanding the role of Shank3 and its interactions with other synaptic proteins is crucial for unraveling the complex mechanisms underlying brain function and neurodevelopmental disorders. Further research on Shank3 may pave the way for potential therapeutic interventions targeting synapse dysfunction in these conditions.
Source	Rabbit
Specificity	Endogenous levels of total SHANK3 can be detected using the SHANK3 antibody. This antibody is specifically designed to recognize and bind to the protein, allowing for its detection in samples. By detecting endogenous levels of SHANK3, researchers can gain insights into the protein's expression and function in various biological processes. The SHANK3 antibody is a valuable tool for studying this important protein and its role in the body.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Sheep;Horse;Pig
Antigen	SHANK3
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human SHANK3.
MW	185 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. Let me generate a highly similar content by rearranging the sentence: The purification of the antiserum involved the use of SulfoLink™ Coupling Resin in peptide affinity chromatography methodology.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal preservation, keep the product at a temperature of -20°C for up to one year. It is important to avoid subjecting the product to multiple freeze and thaw cycles.
Storage buffer	This solution contains Rabbit IgG in phosphate buffered saline at a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20°C. The solution is stable for a period of 12 months from the date of receipt.
Target
Background	Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.
Tissue specificity	Expressed in the cerebral cortex and the cerebellum.
Celluar localization	Cytosol;Plasma Membrane;
UniPort	Q9BYB0