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Rabbit Anti-SCN2B Polyclonal Antibody#abs134816

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Description

Catalog-specification	Delivery time	USD price
abs134816-100ug	1-2 Weeks	301.0
abs134816-50ug	1-2 Weeks	201.0

Overview
catalog	abs134816
Other names	The voltage gated sodium channel beta 2 subunit, also known as Scn 2b or SCN2B_HUMAN, is a crucial component of sodium channels in neuronal cells. The Sodium channel subunit beta 2 plays a key role in regulating the flow of sodium ions across the cell membrane, which is essential for proper neuronal function. This Sodium channel voltage gated type II beta polypeptide has also been implicated in various neurological disorders, including epilepsy and migraines. Understanding the function of the Sodium channel subunit beta-2 is therefore critical for developing effective treatments for these conditions.
Source	Rabbit
Specificity	The SCN2B Antibody can identify total SCN2B levels present within the organism. The detection is specific to endogenous levels of the protein. To generate content with high similarity, we can rephrase it as follows: With the use of the SCN2B Antibody, endogenous amounts of total SCN2B can be recognized. The detection is targeted and can accurately identify the protein levels present within the organism.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Dog
Antigen	SCN2B
Application	The dilution range for Western Blot (WB) is typically 1:500 to 1:1000, while for Immunofluorescence (IF) and Immunocytochemistry (ICC) it is 1:100 to 1:500. ELISA with a peptide antigen usually requires a dilution of 1:20000 to 1:40000. These dilution ranges are commonly used in various assays to obtain optimal results.
Immunogen	A synthesized peptide.
MW	24 KD
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum. Let's construct alternative content by rearranging the original information.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal conditions, it is recommended to store at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the stored item to multiple cycles of freezing and thawing.
Storage buffer	The Rabbit IgG is suspended in a solution of phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C and is stable for a period of 12 months from the date of receipt. To ensure optimal use, it is important to follow the recommended storage and handling procedures. So if you want to make the most of your Rabbit IgG, store it properly and keep it for no more than a year.
Target
Background	Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).
Tissue specificity	Brain specific.
Celluar localization	Plasma Membrane;
UniPort	O60939