Rabbit Anti-PIWIL2 Polyclonal Antibody#abs136692

abs136692-100ug

1-2 Weeks

301.0

abs136692-50ug

1-2 Weeks

201.0

catalog

Description

Argonaute proteins are an important family of proteins, and PIWIL2 is one of them. It plays a crucial role in the development and maintenance of germline stem cells. Specifically, during spermatogenesis, PIWIL2 is responsible for repressing transposable elements and preventing their mobilization. This is essential for ensuring the integrity of the germline. PIWIL2 also plays a vital role in the differentiation of spermatocytes, the differentiation of germ cells, and the self-renewal of spermatogonial stem cells.
Interestingly, PIWIL2 has been found to be present in oocytes as well, suggesting that it may have similar functions during oogenesis in females. In addition to its role in stem cell maintenance and differentiation, PIWIL2 indirectly modulates the expression of certain genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9, and STRA8.
Furthermore, it has been observed that PIWIL2 can inhibit the growth of tumor cells when repressed. However, when overexpressed, it acts in an oncogenic manner by inhibiting apoptosis and promoting proliferation in tumors.
In summary, PIWIL2 is a crucial protein involved in the regulation of stem cells, the preservation of germline integrity, and the differentiation of germ cells. Its presence in both male and female reproductive cells highlights its significance in reproductive processes. Additionally, its role in tumor cell growth underscores its potential as a target for therapeutic interventions.

Concentration

1mg/ml

Target

Background

Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660).