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Rabbit Anti-PEBP1 Polyclonal Antibody#abs134592

Description

Catalog-specification	Delivery time	USD price
abs134592-50ug	1-2 Weeks	201.0
abs134592-100ug	1-2 Weeks	301.0

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Overview
catalog	abs134592
Other names	Prostatic binding protein, also known as epididymis luminal protein 210 or HEL 210, plays a crucial role in the reproductive system. Its other aliases, such as Neuropolypeptide h3 or Raf kinase inhibitory protein, highlight its diverse functions. This multifunctional protein, encoded by the PEBP1 gene, displays various roles, from binding to phosphatidylethanolamine to regulating cholinergic neurostimulation in the hippocampus. Epididymis secretory protein Li 34, HEL S 34, or PEBP-1, is a close relative of PEBP. It shares its binding affinity to phosphatidylethanolamine and contributes to the proper functioning of the epididymis. Its similarity to Epididymis secretory protein Li 96 and HEL S 96 suggests their involvement in the same biological pathways, possibly related to cholinergic signaling. Another significant member of this protein family is HCNP, or Hippocampal cholinergic neurostimulating peptide, which highlights its specific role in the hippocampus. HCNPpp, the phosphorylated form of HCNP, may possess enhanced activity or stability compared to its non-phosphorylated counterpart. Overall, these proteins, collectively known as phosphatidylethanolamine binding proteins, play crucial roles in various biological processes, ranging from reproductive function to neuronal signaling. Their intricate interplay and precise mechanisms of action continue to be a subject of scientific exploration.
Source	Rabbit
Specificity	The PEBP1 Antibody is designed to specifically recognize and measure the levels of total PEBP1 protein present in cells or tissues. This antibody is capable of detecting the endogenous levels of PEBP1 without any interference from other proteins. The detection of total PEBP1 provides valuable insights into its expression and can be used for various research purposes. To summarize, the PEBP1 Antibody is a reliable tool for assessing the amount of PEBP1 protein in biological samples.
Species Reactivity	Human
Antigen	PEBP1
Application	For Western Blot, a dilution of 1:500 to 1:1000 is recommended. When it comes to Immunofluorescence and Immunocytochemistry, a dilution range of 1:100 to 1:500 should be used. And for ELISA with peptide, a dilution range of 1:20000 to 1:40000 is suggested. It is important to note that these dilutions may vary depending on the specific experimental conditions and the antibody being used.
Immunogen	A synthesized peptide.
MW	23 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography to obtain a purified product.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it's advisable to store it at a temperature of -20 °C for a year. It's important to avoid subjecting the product to repeated freeze-thaw cycles as this could affect its stability.
Storage buffer	The storage condition for Rabbit IgG is as follows: it should be stored at -20 °C in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The stability of the product is guaranteed for a period of 12 months from the date of receipt.
Target
Background	Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;
UniPort	P30086