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Rabbit Anti-NTF3 Polyclonal Antibody#abs135625

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Description

Catalog-specification	Delivery time	USD price
abs135625-50ug	1-2 Weeks	201.0
abs135625-100ug	1-2 Weeks	301.0

Overview
catalog	abs135625
Description	Neurotrophin-3, or NT-3, is a protein belonging to the neurotrophin family, which includes other related proteins such as β-NGF, BDNF and NT-4. NT-3 is expressed in different cell types, including neuronal cells, eosinophils, and melanocytes. Its role in the development of peripheral sensory neurons is essential. It is initially synthesized as a precursor protein that is later cleaved into its mature form. NT-3 signaling is transmitted through two receptors, the p75NTR and TrkC. Interestingly, while all neurotrophins bind to the p75NTR receptor, NT-3 demonstrates a higher affinity for binding to TrkC, and a lesser affinity for binding to TrkB.
Other names	Neurotrophin-3, also known as NT-3 or NTF3, is a neurotrophic factor that promotes the growth and survival of nerve cells. It is encoded by the HDNF (MGC129711) gene and is a precursor protein that is processed into its mature form. NGF-2 is another name for NT-3 and is responsible for supporting the growth and maintenance of certain types of neurons. NT-3 is important for the development and maintenance of the nervous system and has been investigated as a potential therapeutic target for neurodegenerative diseases. Overall, the many names for this protein reflect its importance in neurobiology and the ongoing research into its therapeutic potential.
Source	Rabbit
Specificity	The total level of endogenous NTF3 can be detected using the NTF3 Antibody. To produce similar content, simply rearrange the original text information accordingly.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;
Antigen	NTF3
Application	For Western blotting, diluted concentrations of 1:500 to 1:2000 are recommended. Immunohistochemistry requires a dilution range of 1:50 to 1:200. When conducting an ELISA using peptide, it is suggested to dilute the sample at 1:20000 to 1:40000. Keep in mind these are general guidelines and may vary depending on the specificity and sensitivity of the antibody being used.
Immunogen	A synthesized peptide derived from human NTF3.
MW	29kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Seems to promote the survival of visceral and proprioceptive sensory neurons.
Tissue specificity	Brain and peripheral tissues.
Celluar localization	Extracellular region or secreted;
UniPort	P20783