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Rabbit Anti-CD79B Polyclonal Antibody#abs136287

Please note that the price mentioned above is for your reference only. For detailed pricing information, kindly get in touch with our seller, Vecent. We appreciate your understanding. Western blot analysis of extracts of mouseliver tissue cell line, using CD79B antibody. This product is for...

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Description

Catalog-specification	Delivery time	USD price
abs136287-100ug	1-2 Weeks	301.0
abs136287-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is for your reference only. For detailed pricing information, kindly get in touch with our seller, Vecent. We appreciate your understanding.

Overview
catalog	abs136287
Description	The core of the B lymphocyte antigen receptor is a complex made up of multiple components, with one of them being the antigen-specific surface immunoglobulin (Ig). Together with Ig-alpha and Ig-beta, which bind to surface Ig in a non-covalent manner, the B-cell antigen receptor is formed and able to function properly. The gene described here is responsible for encoding the Ig-beta protein, which is an essential component of the B-cell antigen receptor. Various transcript variants of this gene have been identified, resulting in the production of different isoforms of Ig-beta. This information was provided by RefSeq in July 2008.
Other names	B-cell specific glycoprotein B29, also known as B-cell antigen receptor complex-associated protein beta chain or CD79b, is a crucial component of the B-cell antigen receptor complex. It plays a vital role in the signaling and activation of B cells. CD79b is a glycoprotein that specifically associates with the B-cell receptor and is essential for its proper function. CD79b, also referred to as Ig-beta or Igbeta, is encoded by the CD79B gene in humans. It is a molecule that is closely associated with immunoglobulins and is involved in the antigen recognition process of B cells. CD79b is responsible for transmitting signals from the B-cell receptor to the intracellular signaling pathways, leading to B-cell activation and subsequent immune response. The CD79b protein is highly expressed in B cells and forms a complex with CD79a, another component of the B-cell receptor complex. This complex is crucial for the assembly and surface expression of the B-cell receptor, as well as for signal transduction upon antigen binding. CD79b acts as an important adaptor molecule, linking the B-cell receptor to downstream signaling molecules and regulating B-cell development, activation, and survival. Overall, CD79b is an integral component of the B-cell antigen receptor complex, playing a critical role in B-cell function and immune response. Its association with immunoglobulins and its involvement in signal transduction pathways make CD79b a key player in B-cell biology.
Source	Rabbit
Specificity	The CD79B Antibody is capable of detecting total CD79B levels that are present within the organism. This detection occurs at the endogenous level. If you wish to generate content that closely resembles the original text, you may rearrange the information in order to achieve this goal.
Species Reactivity	Human;Mouse;Rat
Antigen	CD79B
Application	The recommended dilutions for WB are between 1:500 and 1:2000, while for IHC they are between 1:50 and 1:200. For ELISA assays using a peptide, a dilution of 1:20000 to 1:40000 is suggested. It is important to use these dilutions to ensure the optimal and accurate results of your experiments.
Immunogen	A synthesized peptide derived from human CD79B.
MW	35kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Tissue specificity	B-cells.
Posttranslational modification	Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.
Celluar localization	Cytosol;Extracellular region or secreted;Golgi apparatus;Nucleus;Plasma Membrane;
UniPort	P40259