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Phospho-c-Fes (Tyr713) Rabbit Polyclonal Antibody#abs139870

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Description

Catalog-specification	Delivery time	USD price
abs139870-100ug	1-2 Weeks	301.0
abs139870-50ug	1-2 Weeks	201.0

Overview
catalog	abs139870
Other names	C-Fes/Fps protein is also known as cFES or Feline Sarcoma (Snyder Theilen) Viral (v fes)/Fujinami Avian Sarcoma (PRCII) Viral (v fps) Oncogene Homolog. This protein is associated with feline sarcoma and Fujinami avian sarcoma oncogene. It is a proto-oncogene tyrosine kinase known as FES_HUMAN or FES proto-oncogene, tyrosine kinase. The Fes protein plays a crucial role in cell signaling and regulation. It is involved in various cellular processes, including cell growth, survival, and differentiation. The mutated form of Fes can lead to the development of cancer. FES is commonly found in feline sarcoma virus and has been linked to oncogenic transformation. The protein P93c fes is a specific isoform associated with the feline sarcoma virus. The proto-oncogene tyrosine-protein kinase Fes/Fps is essential in the regulation of signal transduction pathways. Understanding the functions and mechanisms of Fes is crucial in unraveling the complexities of oncogenesis and developing targeted therapies for cancer treatment. Further research is needed to explore the full potential of Fes as a therapeutic target.
Source	Rabbit
Specificity	The c-Fes (Phospho-Tyr713) Antibody specifically identifies and binds to c-Fes proteins in their phosphorylated state at Tyr713. It is capable of detecting the naturally occurring levels of endogenous c-Fes only when it is phosphorylated at Tyr713.
Species Reactivity	Human
Predictive reaction species	Pig
Antigen	c-Fes
Application	In order to achieve optimal results, it is recommended to use dilutions of WB 1:1000-3000, IHC 1:50-1:200, and ELISA (peptide) 1:20000-1:40000. These dilutions have been shown to produce highly reliable and accurate data in various research settings. Whether you are conducting Western blotting, immunohistochemistry, or enzyme-linked immunosorbent assay, it is essential to find the right dilution ratio to obtain accurate and reproducible results. Therefore, it is highly recommended to follow these dilution guidelines for optimal performance and reliable data analysis.
Immunogen	Human c-Fes is a protein from which a synthesized peptide, specifically Phospho-Tyr713, has been derived. For the purpose of generating highly similar content, the original text information should be rearranged.
MW	93kDa.
Properties
Concentration	1mg/ml
purification	The highly specific antibody was obtained from rabbit serum that underwent purification through a series of chromatography processes involving phospho- and non-phospho-peptide affinity columns. The purified serum allowed for the isolation of the desired antibody, ensuring a high level of similarity to the original target antigen.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
Tissue specificity	Widely expressed. Detected in adult colon epithelium.
Posttranslational modification	Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK.
Celluar localization	Cytoskeleton;Cytosol;Golgi apparatus;Plasma Membrane;
UniPort	P07332