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Phospho-MER/TYRO3 (Tyr753/Tyr685) Rabbit Polyclonal Antibody#abs140272

Phospho-MER/TYRO3 (Tyr753/Tyr685) Rabbit Polyclonal Antibody#abs140272

Please note that the mentioned price is only for your reference. For detailed pricing information, please get in touch with our sales representative, Vecent. Western blot analysis MER/TYRO3 (Phospho-Tyr753/Tyr685) using K562 whole cell lysates This product is for research use only, not for use...

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Description

Catalog-specificationDelivery timeUSD price

abs140272-100ug

1-2 Weeks

301.0

abs140272-50ug

1-2 Weeks

201.0

Please note that the mentioned price is only for your reference. For detailed pricing information, please get in touch with our sales representative, Vecent.


Overview

catalog

abs140272
Other namesc-Mer is a proto-oncogene tyrosine kinase that plays a crucial role in cell signaling pathways. It is also known as cMER, cmer protooncogene tyrosine kinase, Eyk, MER, MER receptor tyrosine kinase, MERK, MERPEN, Mertk, MERTK c-mer proto-oncogene tyrosine kinase, MERTK_HUMAN, MGC133349, nmf12, Nyk, Proto oncogene tyrosine protein kinase MER, Proto oncogene tyrosine protein kinase MER precursor, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, RP38, STK kinase, Tyrosine-protein kinase Mer, Brt, BYK, DTK, Etk-2, protein tyrosine kinase 3, Rek, RSE, SKY, Tif, tyro3, TYRO3 protein tyrosine kinase, TYRO3_HUMAN, Tyrosine-protein kinase byk, Tyrosine-protein kinase DTK, Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase RSE, Tyrosine-protein kinase SKY, and Tyrosine-protein kinase TIF.
It is important to rearrange and reshuffle this existing information to generate a different and unique content that is not a direct reproduction of the original text.
SourceRabbit
SpecificityThe Antibody against MER/TYRO3 (Phospho-Tyr753/Tyr685) is capable of detecting endogenous levels of MER/TYRO3, but only when it is phosphorylated at Tyr753/Tyr685. Therefore, it specifically recognizes the phosphorylated form of the protein.
Species ReactivityHuman;Mouse;Rat
Predictive reaction speciesXenopus;Rabbit;Pig;Dog;Sheep;Bovine;Horse
AntigenMER/TYRO3
ApplicationThe recommended dilution range for Western Blot (WB) is between 1:1000 and 1:3000. When performing Immunofluorescence (IF) or Immunocytochemistry (ICC), a dilution range of 1:100 to 1:500 is commonly used. For Enzyme-Linked Immunosorbent Assay (ELISA) with peptide detection, the suggested dilution range is from 1:20000 to 1:40000.
ImmunogenA peptide synthesized from the human protein MER/TYRO3, specifically targeting Phospho-Tyr753/Tyr685, has been developed. The synthesized peptide closely resembles the original protein sequence, ensuring functional efficacy and specificity. This advancement holds potential for future applications in the diagnosis, treatment, and prevention of diseases related to MER/TYRO3 dysregulation.
MW110KD
Properties

Concentration

1mg/ml

purificationThe sequential chromatography technique was used to purify the antibody from rabbit serum, specifically through affinity purification on phospho- and non-phospho-peptide affinity columns. This process involved purifying the antibody by selectively binding it to these columns and subsequently isolating it.
ClonalityPolyclonal Antibody
Stability & StorageStore at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage bufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Target

Background

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Tissue specificityNot expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.
Posttranslational modificationAutophosphorylated on Tyr-749, Tyr-753 and Tyr-754 in the activation loop allowing full activity. Autophosphorylated on Tyr-872 leading to recruitment of downstream partners of the signaling cascade such as PLCG2 (By similarity).
Celluar localizationExtracellular region or secreted;Plasma Membrane;
UniPortQ12866/Q06418


Western blot analysis MER/TYRO3 (Phospho-Tyr753/Tyr685) using K562 whole cell lysates


This product is for research use only, not for use in diagnostic prodecures or in human.


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