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Rabbit Anti-TFAP2D Polyclonal Antibody#abs132800

Please note that the stated price is for your reference only. For specific pricing details, kindly get in touch with our salesperson, Vecent. Western blot analysis of TFAP2D expression in TFAP2D transfected 293T cell lysate,The lane on the left is treated with the antigen-specific peptide. This...

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Description

Catalog-specification	Delivery time	USD price
abs132800-100ug	1-2 Weeks	301.0
abs132800-50ug	1-2 Weeks	201.0

Please note that the stated price is for your reference only. For specific pricing details, kindly get in touch with our salesperson, Vecent.

Overview
catalog	abs132800
Description	AP-2 factors are DNA-binding proteins that have a specific affinity for inducible viral and cellular enhancer elements. These factors play a crucial role in regulating the transcription of certain genes. They bind to a consensus sequence known as 5'-GCCNNNGGC-3', which allows them to activate the expression of genes involved in various important biological processes such as eye, face, body wall, limb, and neural tube development. Interestingly, AP-2 factors not only promote the activation of specific genes but also act as suppressors of other genes. For instance, they can suppress the expression of genes like MCAM/MUC18, C/EBP alpha, and MYC. This regulatory role enables AP-2 factors to finely tune gene expression and contribute to the intricate balance necessary for proper development and function. In summary, AP-2 factors are sequence-specific DNA-binding proteins that serve as vital regulators of gene transcription. Their binding to specific enhancer elements allows them to activate genes involved in various biological functions related to development. Furthermore, they can repress the expression of certain genes to maintain the appropriate gene expression profiles. This intricate control ensures the orchestration of key biological processes essential for proper development.
Other names	1. Activating enhancer-binding protein 2-delta, also known as AP2 delta or TFAP2D, is a transcription factor that plays a role in gene regulation. 2. Activating enhancer binding protein 2 beta like 1, or AP2BL1, is another transcription factor involved in gene expression. 3. Both AP2 delta and AP2BL1 are part of the AP-2 family of transcription factors. 4. Transcription factor AP-2-delta, also referred to as TFAP2D, is responsible for activating specific genes and controlling various biological processes. 5. Transcription factor AP 2 beta like 1, also known as TFAP2BL1, shares similarities with AP2 delta and is involved in similar regulatory functions. 6. Collectively, these transcription factors play crucial roles in development, differentiation, and disease progression. 7. Understanding the intricate mechanisms by which AP2 delta and AP2BL1 function can provide insights into their potential therapeutic applications. 8. Further research is needed to fully unravel the complexities of AP2 delta and AP2BL1 signaling pathways and their impact on human health.
Source	Rabbit
Specificity	Total TFAP2D levels can be detected using the TFAP2D antibody, which specifically binds to the endogenous TFAP2D protein.
Species Reactivity	Human;Mouse
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	TFAP2D
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	50 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity).
Tissue specificity	Highly expressed in brain, placenta, skeletal muscle, thymus, small intestine, and prostate, and expressed at lower levels in leukocyte, spleen, testis, ovary and colon. Barely detectable in heart, kidney, liver, lung or pancreas.
Celluar localization	Nucleus;
UniPort	Q7Z6R9