Rabbit Anti-MORF4L1 Polyclonal Antibody #abs130420

abs130420-50ug

1-2 Weeks

201

abs130420-100ug

1-2 Weeks

301

Description

MORF4L1 is a crucial component of the NuA4 histone acetyltransferase (HAT) complex that plays a major role in activating transcription of specific genes. This activation is primarily achieved by acetylating histones H4 and H2A, which leads to modification of nucleosome-DNA interactions and promotes interaction of the modified histones with other transcriptional regulatory proteins.
The NuA4 HAT complex is known to be involved in the activation of transcriptional programs that are responsible for various cellular processes such as oncogene and proto-oncogene mediated growth induction, arrest of growth by tumor suppressors, DNA repair, apoptosis and replicative senescence.
Thus, MORF4L1 is a crucial factor that coordinates the regulation of gene expression by modifying chromatin structure, which is essential for the proper functioning of cells and maintenance of cellular homeostasis.

Other names

The gene CG6363, also known as Morf4l1 or MORFRG15, encodes a protein called Mortality Factor 4-like protein 1 (MRG15). MRG15 is an Esa1p associated factor 3 homolog and is also a transcription factor-like protein. It is involved in regulating gene expression and has been associated with survival of organisms. There is a related gene on chromosome 15 called MORF-related gene 15 protein (MEAF3). MRG15 has been observed to associate with Eaf3 and Protein MSL3-1.
FWP006 and HsT17725 are additional names for this gene and protein. The genetic sequence for MRG15 has been conserved across different species, including humans. Studies have shown that MRG15 is involved in the regulation of DNA replication and repair, as well as in the control of cellular senescence.
S863-6 is another name for MRG15 and is used in scientific literature to refer to this protein. MRG15 has been the subject of several studies investigating its function and potential use in therapy for different diseases. Its role in gene regulation makes it an important target for research and understanding of cellular processes.

Source

Rabbit

Specificity

The MORF4L1 Antibody is capable of detecting the naturally occurring amounts of MORF4L1 within the human body. The antibody is designed to recognize and bind to the specific structures of this protein, allowing for accurate measurements of its levels. With reliable detection capabilities, this antibody is an essential tool for researchers studying the functions and interactions of MORF4L1 with various cellular pathways. Whether studying disease mechanisms, drug development, or basic molecular biology, the MORF4L1 Antibody is a valuable resource for gaining insights into this essential protein.

Species Reactivity

Human;Mouse;Rat

Application

We recommend using a dilution of 1:500-1:2000 for Western Blotting, 1:100-1:500 for Immunofluorescence/Immunocytochemistry, and 1:20000-1:40000 for ELISA with peptide substrate. It is important to note that these dilution ranges may vary depending on the experimental conditions and the specificity of the primary antibody. Proper dilution ensures optimal signal-to-noise ratio and avoids non-specific binding.

Immunogen

A synthesized peptide derived from human MORF4L1.

Properties

Concentration

1mg/ml

Purification

Using SulfoLink™ Coupling Resin, the antiserum underwent peptide affinity chromatography purification. A highly similar content can be generated by rearranging the information from the original text.

Clonality

Polyclonal Antibody

Stability & Storage

To maintain stability, it is recommended to store the product at a temperature of minus 20 degrees Celsius for a period of one year. It is important to avoid subjecting the product to multiple freeze-thaw cycles as it may affect its quality.

Storage buffer

The storage condition for Rabbit IgG is to keep it at -20 °C in a solution of phosphate buffered saline with a pH of 7.4. The solution also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This product remains stable for a period of 12 months starting from the date of its receipt.

Target

Background

The NuA4 histone acetyltransferase (HAT) complex is comprised of various components that function to activate transcription of specific genes by acetylating nucleosomal histones H4 and H2A. This modification can modify the way nucleosomes interact with DNA and allow for interaction between these modified histones and other proteins that positively regulate transcription. The complex plays a vital role in activating transcriptional programs that are associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest, DNA repair, apoptosis, and replicative senescence. The RUVBL1 and RUVBL2 proteins associate with EP400 to contribute to the ATPase and helicase activities of the NuA4 complex. Moreover, NuA4 is recruited to sites of DNA damage where it may play a direct role in DNA repair.
The mSin3A complex works to repress transcription by deacetylating nucleosomal histones, and NuA4 is a component of this complex. NuA4 is required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). It is involved in localizing PALB2, BRCA2, and RAD51 to DNA-damage foci, but not BRCA1.

Celluar localization

Nucleus;

UniPort

Q9UBU8