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Rabbit Anti-BMP-8 Polyclonal Antibody#abs138027

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Description

Catalog-specification	Delivery time	USD price
abs138027-100ug	1-2 Weeks	301.0
abs138027-50ug	1-2 Weeks	201.0

Overview
catalog	abs138027
Other names	BMP-8, also known as bone morphogenetic protein 8 (osteogenic protein 2) or OP-2, is a crucial protein involved in bone development and growth. It plays a significant role in regulating the balance between bone formation and resorption. There are two main isoforms of BMP-8: BMP-8A and BMP-8B. These isoforms, also referred to as Bmp8a and Bmp8b, respectively, share a high degree of similarity in their amino acid sequences. They are encoded by different genes but contribute to similar biological processes. BMP-8A and BMP-8B are essential for maintaining skeletal integrity and promoting bone formation. They act as signaling molecules and bind to specific receptors on bone cells, ultimately leading to the activation of various downstream pathways that regulate bone growth. In addition to their roles in bone development, BMP-8A and BMP-8B have been implicated in other physiological processes. They are involved in embryonic development, tissue repair, and the regulation of cell differentiation. Overall, the bone morphogenetic protein 8 family, including BMP-8A and BMP-8B, is crucial for skeletal development and maintenance. Their functions extend beyond bone formation, highlighting their significance in various biological processes.
Source	Rabbit
Specificity	The antibody for BMP-8 is capable of detecting the entire range of naturally occurring BMP-8. This means it can be used to identify endogenous levels of the protein. If you're looking for a method of quickly and effectively detecting BMP-8 in your research, this antibody is an ideal solution. By recognizing the protein at its core, you can gain valuable insights into its function and behavior, leading to new discoveries and breakthroughs in your field of study.
Species Reactivity	Human;Mouse
Antigen	BMP-8
Application	The dilutions for western blot (WB) range from 1:1000 to 1:3000, for immunohistochemistry (IHC) it is 1:200, and for ELISA (peptide) it is 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human BMP-8.
MW	44 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was achieved through peptide affinity chromatography. To obtain a highly purified antiserum, this technique was utilized.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of this product, it should be stored at a temperature of minus 20 degrees Celsius for a period of one year. It is important to prevent the product from undergoing repeated freeze and thaw cycles as it can affect its quality and effectiveness. Please make sure to follow these storage instructions carefully.
Storage buffer	Phosphate buffered saline with 50% glycerol, pH 7.4, containing 150mM NaCl, rabbit IgG, and 0.02% sodium azide should be stored at -20 °C. It is worth noting that this solution remains stable for a duration of 12 months from the date of receipt.
Target
Background	Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity).
Celluar localization	Extracellular region or secreted;
UniPort	P34820/Q7Z5Y6