Rabbit Anti-Collagen VII Alpha1 Polyclonal Antibody#abs138421
Note: The price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our seller Vecent. We encourage you to reach out to Vecent for accurate and up-to-date pricing details. Western blot analysis Collagen VII α1 using HeLa whole cell lysates This...
Description
| Catalog-specification | Delivery time | USD price |
abs138421-100ug | 1-2 Weeks | 301.0 |
abs138421-50ug | 1-2 Weeks | 201.0 |
Note: The price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our seller Vecent. We encourage you to reach out to Vecent for accurate and up-to-date pricing details.
| Overview | |
catalog | abs138421 |
| Other names | The alpha 1 type VII collagen, also known as CO7A1_HUMAN, Col7a1, Collagen alpha-1(VII) chain, Collagen type VII alpha 1, and Collagen VII alpha 1 polypeptide, is a crucial component of the skin. This collagen, also referred to as EBD 1, EBD1, EBDCT, EBR 1, EBR1, LC collagen, or Long-chain collagen, forms long chains that provide structural support and elasticity to the skin. Without this collagen, the skin becomes fragile and prone to tearing and blistering. The alpha 1 type VII collagen is also important in other connective tissues, including the cornea, joints, and blood vessels. Mutations in the COL7A1 gene, which encodes this collagen, can lead to genetic diseases such as epidermolysis bullosa (EB), a group of skin disorders characterized by blister formation and damage. Research on this collagen is ongoing, and new therapies for EB and other genetic disorders may emerge from a better understanding of its structure and function. |
| Source | Rabbit |
| Specificity | The antibody for Collagen VII α1 is able to recognize and bind to all forms of Collagen VII α1 that are naturally present in the body. This means that it can be used to detect the total amount of this protein in biological samples. It is important to note that the antibody is specific to Collagen VII α1 and will not bind to other proteins, making it a valuable tool for researchers studying the properties and functions of this protein in various contexts. By using this antibody, researchers can gain insights into the role of Collagen VII α1 in health and disease and develop new therapeutic strategies that target this important protein. |
| Species Reactivity | Human;Mouse |
| Antigen | Collagen VII alpha1 |
| Application | WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | A peptide has been synthesized using human Collagen VII α1 as the source material. The resulting peptide is closely related in structure and function to the original protein. This peptide has potential therapeutic applications in the treatment of various skin disorders and wound healing. Additionally, this synthesized peptide may be useful in studying the biology and pathophysiology of Collagen VII α1. Overall, the development of this synthesized peptide represents an important step towards improving our understanding of the role of Collagen VII α1 in various biological processes. |
| MW | 295 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The purification of the antiserum involved the utilization of SulfoLink™ Coupling Resin for peptide affinity chromatography. We employed this resin to purify the antiserum effectively, ensuring its high quality and specificity. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To preserve the quality of the product, keep it at a temperature of -20°C for a period of one year. Prevent the product from being subjected to repeated freeze-thaw cycles, as this may affect its efficacy and performance. |
| Storage buffer | The storage condition of Rabbit IgG is at -20 °C in phosphate buffered saline with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The stability of the product is guaranteed for 12 months from the date of receipt. |
Target | |
Background | Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. |
| Posttranslational modification | Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. |
| Celluar localization | Endoplasmic reticulum;Extracellular region or secreted;Golgi apparatus; |
| UniPort | Q02388 |
Western blot analysis Collagen VII α1 using HeLa whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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