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Rabbit Anti-Netrin-1 Polyclonal Antibody#abs138099

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Description

Catalog-specification	Delivery time	USD price
abs138099-100ug	1-2 Weeks	301.0
abs138099-50ug	1-2 Weeks	201.0

Overview
catalog	abs138099
Other names	There are several different forms of proteins associated with the epididymis tissue, including Li 131P and NET1_HUMAN. Additionally, there are homologs of the mouse protein Netrin 1, as well as other variants such as Netrin 1-like and Netrin-1. Collectively, all of these proteins belong to the family of NTN1 proteins, which are known to play important roles in various cellular processes. Some of the specific functions associated with NTN1 include axon guidance, cell migration, and tumor suppression. Despite the varied forms of these proteins, there is a high degree of similarity between them, which underscores the importance of their role in physiological processes.
Source	Rabbit
Specificity	The detection of endogenous levels of total Netrin-1 is feasible using the Netrin-1 Antibody. This antibody is specifically designed to recognize and bind to the Netrin-1 protein, enabling researchers to quantify its presence. By employing this antibody, scientists can gain insights into the expression and regulation of Netrin-1 within biological systems.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Pig;Sheep;Bovine;
Antigen	Netrin-1
Application	The recommended dilution for Western Blot (WB) ranges from 1:1000 to 1:3000. For Immunohistochemistry (IHC), the suggested dilution is 1:200. As for the ELISA assay using a peptide, it is advised to dilute at a range of 1:20000 to 1:40000. It's important to note that the generated content should be based on the provided information and not follow the conversation style of ChapGPT.
Immunogen	A synthesized peptide derived from human Netrin-1.
MW	67 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed in purifying the antiserum through peptide affinity chromatography. A highly similar variation of the given content could be generated by rephrasing it as follows: "The process of purifying the antiserum involved utilizing SulfoLink™ Coupling Resin in peptide affinity chromatography."
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. Caution must be taken to avoid subjecting the product to repeated freeze and thaw cycles.
Storage buffer	The rabbit IgG is stored in a phosphate buffered saline solution with a pH of 7.4. The solution contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C and remains stable for 12 months from the date of receipt.
Target
Background	Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Tissue specificity	Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level).
Celluar localization	Extracellular region or secreted;
UniPort	O95631