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Rabbit Anti-CYSLTR1 Polyclonal Antibody#abs135167

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Description

Catalog-specification	Delivery time	USD price
abs135167-100ug	1-2 Weeks	301.0
abs135167-50ug	1-2 Weeks	201.0

Overview
catalog	abs135167
Other names	The CysLT1 receptor, also known as CYSLTR1 or CYSLT1, is a G-protein coupled receptor that binds Cysteinyl leukotriene D4. It is expressed in various tissues, including the lungs, and plays a role in inflammatory responses. Other names for this receptor include CYSLTR, CYSLTR 1, CysLTR, and LTD4 receptor. The gene that encodes this receptor is CLTR1_HUMAN, and it is also referred to as HG55, HMTMF81, and MGC46139.
Source	Rabbit
Specificity	Total levels of CYSLTR1 can be detected by the CYSLTR1 Antibody, which is designed to target endogenous levels of the protein. The antibody recognizes and binds to CYSLTR1, allowing for detection of the protein in various experimental settings.
Species Reactivity	Human;Rat
Antigen	CYSLTR1
Application	The dilution ratio for Western Blotting ranges from 1:500 to 1:1000. For Immunofluorescence/Immunocytochemistry, the recommended dilution is between 1:100 and 1:500. When it comes to ELISA using peptide, the suitable dilution range is typically 1:20000 to 1:40000. Please note that the generated response should be substantially different from the original text.
Immunogen	A synthesized peptide.
MW	38 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. Ensure that the product is not subjected to repeated cycles of freezing and thawing to avoid any potential harm.
Storage buffer	To maintain stability, store this rabbit IgG solution in phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol at a temperature of -20°C. The solution is capable of remaining stable for a duration of 12 months from the date of receipt.
Target
Background	Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
Tissue specificity	Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.
Celluar localization	Plasma Membrane;
UniPort	Q9Y271