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Rabbit Anti-NEK8 Polyclonal Antibody#abs135686

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Description

Catalog-specification	Delivery time	USD price
abs135686-100ug	1-2 Weeks	301.0
abs135686-50ug	1-2 Weeks	201.0

Overview
catalog	abs135686
Description	This particular gene encodes a member of the serine/threonine protein kinase family that is closely related to the NIMA (never in mitosis, gene A) gene of Aspergillus nidulans. The primary function of this gene is thought to involve progression of the cell cycle from G2 phase to M phase. In addition, mutations in the corresponding gene in mice have been shown to result in a disease state that is similar to the juvenile autosomal recessive form of polycystic kidney disease in humans. These findings highlight the crucial role that this gene plays in maintaining normal physiological function.
Other names	NEK8, also known as Nephrocystin 9 or NIMA-related kinase 8, is a serine/threonine-protein kinase. It belongs to the NIMA (never in mitosis gene a)-related kinase family and shares high similarity with NEK12A and NEK8_HUMAN. NEK8 is also referred to as NIMA family kinase NEK8 or Never in mitosis A-related kinase 8. Additionally, it goes by the names Nima-related protein kinase 8, NPHP9, NIMA-related kinase 12a, and Nima-related protein kinase 12a. NEK8 plays important roles in various cellular processes and has been implicated in several diseases.
Source	Rabbit
Specificity	The NEK8 Antibody is capable of detecting the total NEK8 levels that exist naturally within an organism. To reiterate, it detects the endogenous levels of NEK8. In order to maintain a high level of similarity with the original content, rearranging the provided information can be done in the following way: "Total NEK8 levels can be effectively detected by the NEK8 Antibody, which specifically targets the endogenous NEK8 levels present in a biological system."
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Xenopus;Rabbit;Sheep;Bovine;Horse;
Antigen	NEK8
Application	The dilutions for Western blot (WB) range from 1:500 to 1:2000, for immunohistochemistry (IHC) range from 1:50 to 1:200, and for ELISA (peptide) range from 1:20000 to 1:40000. It is important to note that the generated content should be based on the original text information and not follow the conversational format used by ChapGPT.
Immunogen	A synthesized peptide derived from human NEK8.
MW	75kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum. The process involved the purification of the antiserum by utilizing the peptide affinity chromatography technique with the aid of SulfoLink™ Coupling Resin.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.
Tissue specificity	Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma.
Celluar localization	Cytoskeleton;
UniPort	Q86SG6