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Rabbit Anti-GCSc-gamma Polyclonal Antibody#abs138070

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Description

Catalog-specification	Delivery time	USD price
abs130070-100ug	1-2 Weeks	301.0
abs130070-50ug	1-2 Weeks	201.0

Overview
catalog	abs130070
Description	The claudin family includes claudin 10, which plays a significant role in the specific obliteration of the intercellular space within tight junctions. This obliteration occurs through the cell-adhesion activity of claudin 10, which is independent of calcium.
Other names	CLDN10, also known as Claudin-10 or CPETRL3, is a protein encoded by the CLDN10 gene. It belongs to the Claudin family and is classified as CLDN 10 in humans. The OSP-like protein (OSPL) is another name associated with this protein. The HGNC name for CLDN10 is 2033. CLDN10 is also referred to as OSP L or CPETRL 3.
Source	Rabbit
Specificity	The Claudin 10 antibody can identify total Claudin 10 levels that are naturally present in the body. To create new content based on this information, one possible rearrangement could be: Total Claudin 10 can be detected by using the Claudin 10 antibody at levels that are found within the individual's normal range.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	Claudin 10
Application	For Western blotting, a dilution range of 1:500 to 1:3000 is recommended. When using immunofluorescence or immunocytochemistry, dilute the antibody at a range of 1:100 to 1:500. For ELISA assays using peptides, a dilution range of 1:20,000 to 1:40,000 is recommended. Be sure to follow the appropriate dilution guidelines to ensure optimal results in your experiments.
Immunogen	A peptide that has been synthesized utilizing sequences found within human Claudin 10 is now available. This peptide is designed to closely mimic the naturally occurring protein and has the potential to be used in a variety of research applications. The synthesis process used to create this peptide ensures a high degree of similarity to the original sequence, providing researchers with a powerful tool for further investigation into Claudin 10 and its functions within the body.
MW	25kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. May form permselective paracellular pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. Plays a key role in controlling cation selectivity and transport in the thick ascending limb (TAL) of Henle's loop in kidney.
Celluar localization	Plasma Membrane;
UniPort	P78369