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Rabbit Anti-GCS- Alpha-1 Polyclonal Antibody#abs138071

Description

Catalog-specification	Delivery time	USD price
abs130071-50ug	1-2 Weeks	201.0
abs130071-100ug	1-2 Weeks	301.0

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Overview
catalog	abs130071
Description	The alpha-2 chain for type I collagen, which is the primary fibrillar collagen in most connective tissues, is encoded by this gene. Mutations in this gene have been linked to several disorders, such as osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome. However, the effects of these mutations tend to be milder compared to those observed in the alpha-1 type I collagen gene, as the alpha-2 chain is less abundant. Interestingly, multiple polyadenylation signals give rise to numerous mRNA transcripts for this gene, a characteristic shared by most other collagen genes available.
Other names	I. Alpha 1 type I collagen II. Alpha 2 type I collagen III. Alpha 2 type I procollagen IV. Alpha 2(I) procollagen V. Alpha 2(I)-collagen VI. Alpha-1 type I collagen VII. Alpha1(I) procollagen VIII. CO1A1_HUMAN IX. COL1A1 X. COL1A2 XI. Collagen alpha 1 chain type I XII. Collagen alpha-1(I) chain XIII. Collagen alpha-1(I) chain preproprotein XIV. Collagen I alpha 1 polypeptide XV. Collagen I alpha 2 polypeptide XVI. Collagen of skin, tendon, and bone, alpha-1 chain XVII. Collagen of skin, tendon, and bone, alpha-2 chain XVIII. Collagen type I alpha 1 XIX. Collagen type I alpha 2 XX. EDSC XXI. OI1 XXII. OI2 XXIII. OI3 XXIV. OI4 XXV. Pro-alpha-1 collagen type 1 XXVI. Type I pro-alpha 1 XXVII. Type I procollagen alpha 1 chain XXVIII. Type I procollagen Please rearrange the given list of terms: I. Alpha 1 type I collagen is the collagen protein found in our body, responsible for providing strength and structure to various tissues, such as skin, tendons, and bones. II. Alpha 2 type I collagen is another form of collagen protein present in our body, contributing to the integrity of tissues like skin, tendons, and bones. III. Alpha 2 type I procollagen is the precursor form of alpha 2 type I collagen, which undergoes further modifications to become the functional collagen protein. IV. Alpha 2(I) procollagen refers to the procollagen formed by the combination of alpha 2 type I collagen chains. V. Alpha 2(I)-collagen is yet another term for the collagen protein composed of alpha 2 type I collagen chains. VI. Alpha-1 type I collagen is the primary collagen protein responsible for maintaining the structure and strength of tissues like skin, tendons, and bones. VII. Alpha1(I) procollagen is the precursor form of alpha-1 type I collagen, which undergoes processing to become mature collagen. VIII. CO1A1_HUMAN is the gene symbol for the collagen type I alpha 1 chain protein present in humans. IX. COL1A1 is an abbreviation used to denote the gene encoding the collagen type I alpha 1 chain. X. COL1A2 is the gene symbol for the collagen type I alpha 2 chain protein. XI. Collagen alpha 1 chain type I refers to the specific type of collagen protein forming alpha 1 chains and contributing to tissue structure. XII. Collagen alpha-1(I) chain is the chain formed by collagen type I alpha 1 protein, essential for tissue integrity. XIII. Collagen alpha-1(I) chain preproprotein represents the initial precursor form of collagen alpha-1(I) chain before it undergoes further modifications. XIV. Collagen I alpha 1 polypeptide is the polypeptide chain formed by collagen type I alpha 1 protein. XV. Collagen I alpha 2 polypeptide is the polypeptide chain formed by collagen type I alpha 2 protein. XVI. Collagen of skin, tendon, and bone, alpha-1 chain is the specific collagen chain that contributes to the strength and structure of skin, tendons, and bones. XVII. Collagen of skin, tendon, and bone, alpha-2 chain is the collagen chain present in skin, tendons, and bones, vital for tissue integrity. XVIII. Collagen type I alpha 1 refers to the specific type of collagen protein formed by alpha 1 chains. XIX. Collagen type I alpha 2 represents the specific type of collagen protein formed by alpha 2 chains. XX. EDSC is an abbreviation referring to a specific collagen disorder called Ehlers-Danlos syndrome, which affects the production or structure of collagen. XXI. OI1 is a designation for one type of osteogenesis imperfecta, a genetic disorder characterized by brittle bones, caused by impaired collagen production. XXII. OI2 is a term used to describe another subtype of osteogenesis imperfecta associated with collagen abnormalities and fragile bones. XXIII. OI3 is an abbreviation for a specific type of osteogenesis imperfecta, a condition characterized by defective collagen synthesis and resulting in bone fragility. XXIV. OI4 refers to a particular variant of osteogenesis imperfecta caused by disruptions in collagen production, leading to weakened bones. XXV. Pro-alpha-1 collagen type 1 refers to the precursor form of collagen type I alpha 1, which undergoes processing to become fully functional collagen. XXVI. Type I pro-alpha 1 represents the initial precursor form of the collagen type I alpha 1 protein. XXVII. Type I procollagen alpha 1 chain is the specific chain formed by the precursor form of collagen type I alpha 1 before it is converted into mature collagen. XXVIII. Type I procollagen refers to the precursor form of collagen type I, which later undergoes modifications to form mature collagen.
Source	Rabbit
Specificity	The presence of Collagen I in a sample can be detected by using the Collagen I Antibody, which is capable of detecting endogenous levels of this protein. It is possible to rearrange these sentences to generate a new content, but the meaning and information conveyed will remain similar.
Species Reactivity	Human;Mouse;Rat
Antigen	Collagen I
Application	The dilution ratios for western blot (WB) range from 1:500 to 1:2000. For immunohistochemistry (IHC), the dilution range is 1:50 to 1:200. As for immunofluorescence/immunocytochemistry (IF/ICC), the recommended dilutions are between 1:100 and 1:500. For ELISA using peptide, the dilution range is 1:20000 to 1:40000. It is important to note that I am generating this content by rearranging the given information, and it may not be presented in the same order as the original text.
Immunogen	A peptide that has been synthesized from Collagen I is of human origin. To produce comparable content, rearrange the text to reflect the information in the original statement.
MW	129kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Type I collagen is a member of group I collagen (fibrillar forming collagen).
Tissue specificity	Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
Posttranslational modification	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;
UniPort	P08123