Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-CAS Polyclonal Antibody#abs140386

Please note that the price provided is only for your reference, for detailed pricing information please get in touch with our seller, Vecent. It's important to clarify that the content generated here is not based on ChapGPT, but rather on a language model that ensures a different approach to...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs140386-100ug	1-2 Weeks	301.0
abs140386-50ug	1-2 Weeks	201.0

Overview
catalog	abs140386
Other names	Cellular apoptosis susceptibility protein, also known as Chromosome segregation 1-like protein, plays a crucial role in regulating chromosome segregation during cell division. CSE1 chromosome segregation 1 like protein is responsible for facilitating the export of macromolecules from the nucleus to the cytoplasm and is involved in the transport of proteins from the cytoplasm to the nucleus. Additionally, XPO2, or Exportin-2, is another name for this integral protein, which functions as an Importin-alpha re-exporter. It is worth noting that several synonyms exist, such as Exp2, Chromosome segregation 1 like, and Importin-alpha re-exporter. MGC117283 and MGC130036 are alternative gene IDs for CSE1L, as well. Overall, CSE1 chromosome segregation 1 like protein is a vital protein that participates in various cellular processes and plays a critical role in maintaining cell homeostasis.
Source	Rabbit
Specificity	The CAS Antibody is capable of detecting the total amount of endogenous CAS present in a sample. This means that it can identify all forms of CAS that exist in the sample and provide accurate measurements.
Species Reactivity	Human
Antigen	CAS
Application	We recommend using WB 1:1000 for Western blotting, IF/ICC 1:100-1:500 for immunofluorescence and immunocytochemistry, and ELISA(peptide) 1:20000-1:40000 for enzyme-linked immunosorbent assay. It is important to follow the suggested dilution ratios to ensure accurate results.
Immunogen	A synthesized peptide derived from human CAS.
MW	110kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for the purification of the antiserum through peptide affinity chromatography. The resulting purified product exhibited high levels of similarity to the original substance.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to store at -20 °C for a duration of one year. To maintain the quality, it is important to avoid subjecting the item to multiple freeze and thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Tissue specificity	Detected in brain, placenta, ovary, testis and trachea (at protein level) (PubMed:10331944). Widely expressed (PubMed:10331944). Highly expressed in testis and in proliferating cells (PubMed:7479798,PubMed:10331944).
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;
UniPort	P55060