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Rabbit Anti-SLC5A1 Polyclonal Antibody#abs136722

Hello, please note that the price mentioned above is for reference only. For detailed pricing information, kindly get in touch with our seller Vecent. Thank you. Western blot analysis of extracts of mouse eyetissue lysate, using SLC5A1antibody. This product is for research use only, not for use...

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Description

Catalog-specification	Delivery time	USD price
abs136722-100ug	1-2 Weeks	301.0
abs136722-50ug	1-2 Weeks	201.0

Hello, please note that the price mentioned above is for reference only. For detailed pricing information, kindly get in touch with our seller Vecent. Thank you.

Overview
catalog	abs136722
Description	The SGLT family member encoded by this gene plays a crucial role in the absorption of dietary glucose and galactose from the intestinal lumen. As an integral membrane protein, it serves as the primary mediator in this process. Mutations in this gene have been linked to a condition called glucose-galactose malabsorption. There are multiple transcript variants that produce different isoforms of this gene, each with its own function.
Other names	Sodium glucose cotransporter 1, also known as SGLT1 or Na+/glucose cotransporter 1, is a high-affinity transporter responsible for the uptake of glucose in humans. It belongs to the solute carrier family 5 and is encoded by the SLC5A1 gene. This transporter plays a critical role in glucose homeostasis by facilitating the transport of glucose across cell membranes. It has a high affinity for both sodium and glucose, allowing for efficient glucose absorption in the intestine and reabsorption in the renal tubules. The SGLT1 transporter is essential for maintaining glucose levels in the body and is a target for therapeutic interventions in diseases such as diabetes.
Source	Rabbit
Specificity	The presence of total SLC5A1 can be accurately determined using the SLC5A1 Antibody, which is capable of detecting endogenous levels of the protein. By rearranging the original content, the information is reiterated, stating that the antibody is used to identify the total amount of SLC5A1 present within a sample.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Sheep;Bovine;
Antigen	SLC5A1
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthetic peptide of humanSLC5A1.
MW	60kDa
Properties
Concentration	1mg/ml
purification	A highly similar content can be generated by rearranging the original information as follows: The SulfoLink™ Coupling Resin was used in peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Actively transports glucose into cells by Na+ cotransport with a Na+ to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.
Tissue specificity	Expressed mainly in intestine and kidney.
Posttranslational modification	N-glycosylation is not necessary for the cotransporter function.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P13866