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Rabbit Anti-GDNF Polyclonal Antibody#abs137204

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our sales representative, Vecent. It is essential to contact Vecent for accurate pricing details. Western blot analysis GDNF using NIH-3T3 whole cell lysates This...

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Description

Catalog-specification	Delivery time	USD price
abs137204-100ug	1-2 Weeks	301.0
abs137204-50ug	1-2 Weeks	201.0

Overview
catalog	abs137204
Other names	Glial cell-derived neurotrophic factor (GDNF), also known as astrocyte-derived trophic factor (ADTF) or astrocyte-derived trophic factor 1 (ADTF1), is a protein that plays a crucial role in supporting the survival and function of astrocytes, a type of glial cell in the central nervous system. The ATF1 and ATF2 genes encode these factors, and they are often referred to as ATF proteins. GDNF, or glial cell line-derived neurotrophic factor, is a potent signaling molecule involved in the development and maintenance of the nervous system. It promotes the survival and growth of neurons and has been implicated in various neurological disorders. HFB1 GDNF, also known as hGDNF, is a specific isoform of GDNF. It is associated with a genetic disorder called Hirschsprung disease type 3 (HSCR3), which affects the development of nerves in the colon. These factors have generated significant interest in the field of neurobiology and hold promise for the treatment of various neurological conditions and diseases. Understanding their functions and mechanisms of action could lead to the development of novel therapeutic strategies for conditions such as Parkinson's disease, Huntington's disease, and spinal cord injuries. Further research is needed to fully elucidate the potential therapeutic applications of GDNF and its related factors.
Source	Rabbit
Specificity	The endogenous levels of total GDNF can be effectively detected using the GDNF Antibody.
Species Reactivity	Human
Predictive reaction species	Sheep;Bovine;Horse;Chicken;
Antigen	GDNF
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human GDNF.
MW	24 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed for the purification of the antiserum. Please provide a completely different way of communicating using a language model that generates highly dissimilar content.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, please keep the product stored at -20 °C for one year. It is important to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	This product contains Rabbit IgG in a buffer solution of phosphate and saline, with the addition of NaCl at 150mM concentration, sodium azide at 0.02% concentration, and glycerol at 50%. It should be stored at -20°C and will remain stable for up to 12 months from the date of receipt. Please note that this information is based on the original text and any further questions can be directed to our customer service team.
Target
Background	Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
Tissue specificity	In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change.
Celluar localization	Extracellular region or secreted;
UniPort	P39905