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Phospho-Phospholamban Rabbit Polyclonal Antibody#abs137203

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent. Western blot analysis Phospholamban using 293 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in...

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Description

Catalog-specification	Delivery time	USD price
abs137203-100ug	1-2 Weeks	301.0
abs137203-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent.

Overview
catalog	abs137203
Other names	Phospholamban, also referred to as PLB, is a key protein involved in cardiac function and regulation. It is associated with several cardiac disorders, including dilated cardiomyopathy 1P (CMD1P) and hypertrophic cardiomyopathy 18 (CMH18). Additionally, PLB is encoded by the PPLA_HUMAN gene and plays a critical role in the control of calcium uptake and release in cardiac muscle cells. Overall, the study of cardiac phospholamban is crucial for our understanding of cardiovascular diseases and the development of effective treatments.
Source	Rabbit
Specificity	The detection of Phospholamban Antibody is capable of identifying the natural amounts of Phospholamban within an organism. To create similar content, the given information needs to be rephrased without changing its core meaning. Thus, the statement could be rewritten as follows: The presence of Phospholamban Antibody can be used to recognize the endogenous levels of Phospholamban that exist in a biological system.
Species Reactivity	Human;Mouse;Rat
Antigen	Phospholamban
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	Human Phospholamban has been utilized to synthesize a peptide, which demonstrates a high level of similarity with the original content. The arrangement of this content ensures its derivation from the underlying information present in the initial text.
MW	24 kDa
Properties
Concentration	1mg/ml
purification	By employing SulfoLink™ Coupling Resin, we successfully purified the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Please store at -20 °C for a period of one year to maintain the integrity of the product. It is important to prevent the product from undergoing repeated freeze/thaw cycles. Be cautious and avoid subjecting the product to temperature fluctuations.
Storage buffer	The storage condition for Rabbit IgG is in phosphate buffered saline with a pH of 7.4. It should be mixed with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is advisable to store it at -20 °C. The Rabbit IgG is stable for a period of 12 months from the date of receipt.
Target
Background	By reducing the apparent affinity of the ATPase for Ca2+, the activity of ATP2A2 in cardiac sarcoplasmic reticulum is reversibly inhibited. This inhibition is dependent on the oligomeric state of PLN, which also plays a role in modulating the contractility of the heart muscle in response to physiological stimuli. Additionally, PLN influences calcium re-uptake during muscle relaxation and is crucial for maintaining calcium homeostasis in the heart muscle. It is worth noting that the extent of ATP2A2 inhibition can be relieved through PLN phosphorylation.
Tissue specificity	Heart muscle (at protein level).
Posttranslational modification	Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.
Celluar localization	Endoplasmic reticulum;Mitochondrion;
UniPort	P26678