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Rabbit Anti-SSTR2 Polyclonal Antibody#abs136726

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Description

Catalog-specification	Delivery time	USD price
abs136726-100ug	1-2 Weeks	301.0
abs136726-50ug	1-2 Weeks	201.0

Overview
catalog	abs136726
Description	The inhibitory effects of somatostatin are observed at various sites, impacting the release of multiple hormones and secretory proteins. It is believed that the biological actions of somatostatin are facilitated by a group of G protein-coupled receptors, which show tissue-specific expression patterns. Among these receptors, SSTR2 stands as a key member with its structure consisting of seven transmembrane segments. The highest levels of SSTR2 expression are detected in the cerebrum and kidney. This information has been sourced from RefSeq in July 2008.
Other names	The somatostatin receptor type 2 is also known as SRIF-1 or SS-2-R. It is often abbreviated as SSR2_HUMAN or SST2. Other names for this receptor include SRIF1, SS2-R, and SS2R. It is a protein that is encoded by the SSTR2 gene and serves as a receptor for the hormone somatostatin. This receptor is primarily found in the central nervous system and the gastrointestinal tract, where it plays a crucial role in regulating various physiological processes.
Source	Rabbit
Specificity	The SSTR2 Antibody is capable of detecting the total amount of endogenous SSTR2 in the cell. This means that the antibody can specifically bind to and identify the presence of SSTR2 protein molecules in the sample being examined. The antibody is highly effective in detecting even small amounts of SSTR2 and is therefore used widely in research and diagnostic applications. Its ability to detect total SSTR2 levels makes it an important tool in studying the role of this protein in different cellular processes.
Species Reactivity	Human;Mouse;Rat
Antigen	SSTR2
Application	For Western blotting, the recommended dilutions for antibody are 1:500-1:1000. As for immunohistochemistry, dilutions of 1:50-1:200 are recommended. For ELISA using peptide as the antigen, dilutions of 1:20000-1:40000 are recommended to achieve optimal results. It is important to carefully consider the optimal dilutions of the antibody for each application, as using the wrong dilution can lead to false results.
Immunogen	A synthetic peptide of human SSTR2.
MW	41kDa
Properties
Concentration	1mg/ml
purification	To obtain a purified antiserum, a peptide affinity chromatography technique was employed using SulfoLink™ Coupling Resin.
Clonality	Polyclonal Antibody
Stability & Storage	One year storage is recommended at a temperature of -20 °C. It is important to avoid subjecting the stored items to repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
Tissue specificity	Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.
Posttranslational modification	Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization (By similarity).
Celluar localization	Cytosol;Plasma Membrane;
UniPort	P30874