Rabbit Anti-CD11b/c Polyclonal Antibody #abs120423

abs120423-50ul

In Stock

201

abs120423-100ul

In Stock

301

Other names

The p170 antigen, also known as CD11b, is a cell surface glycoprotein that belongs to the CD11 antigen like family. It is also referred to as CD49d, Cell Surface Glycoprotein MAC1 Alpha Subunit, Complement Component Receptor 3 Alpha, CR3 alpha chain, Integrin Alpha M, Leukocyte Adhesion Receptor MO1, MAC 1, Neutrophil Adherence Receptor, and other names. It is encoded by the ITGAM gene and is part of the integrin αM subunit. The CD11b/CD18 complex, also called MAC1, plays an important role in leukocyte adhesion and is involved in mediating cell-cell interactions. Its function is closely associated with the adherence of neutrophils and other leukocytes. The information provided above has been rearranged to ensure that the content remains highly similar to the original text.

Source

Rabbit

Specificity

CD11b

Species Reactivity

Human;Mouse;Rat;Pig;

Application

：
ELISA1:500-1000，。ELISA，，。。
IHC-PIHC-F1:400-800。。IHC-P，，，。IHC-F，，。
Flow-Cyt1μg/Test，。，。Flow-Cyt，。
IF1:100-500，。，。，。
，IF。。
，。，。

Immunogen

Synthetic peptide KLH-conjugated, derived from the human CD11b:77-180, can be synthesized to obtain a highly similar peptide sequence. To generate a content that closely resembles the original text, the peptide, which is conjugated with KLH, is developed using the sequence derived from human CD11b:77-180. It is important to note that this approach ensures the generation of a peptide with a high degree of similarity based on the information originally provided. It is not recommended to use a conversational style of dialogue for this purpose, but rather a language model that generates substantially different text.

Properties

Concentration

1mg/ml

Purification

affinity purified by Protein A

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

To preserve the product's quality, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting the product to multiple freeze/thaw cycles.

Storage buffer

A solution containing 1% BSA, 0.03% Proclin300, and 50% glycerol in TBS (pH 7.4) with a final concentration of 0.01M is recommended.

Research area

Signal transduction is a key process in cell biology, immunology, and neurobiology, as it plays a crucial role in the way cells communicate with each other and respond to their environment. One important aspect of signal transduction is apoptosis, which is a programmed cell death mechanism that occurs in response to a variety of internal and external signals. Understanding the mechanisms involved in signal transduction and apoptosis is crucial for developing new therapies for a range of diseases, such as cancer, autoimmune disorders, and neurological disorders. Therefore, research in these areas is of high importance in the biomedical field.

Target

Background

The gene under consideration encodes an alpha integrin subunit for the Mac-1 or CR3 leukocyte-specific integrin complex. Integrins are composed of both alpha and beta subunits and are integral membrane proteins. This particular alpha subunit contains an I-domain and combines with the beta 2 subunit (ITGB2) to form a crucial component in the adherence of monocytes and neutrophils to stimulated endothelial cells. Additionally, the alpha M beta 2 integrin plays a key role in the phagocytosis of complement-coated particles. Scientists have identified various transcript variants that express diverse isoforms for this gene. [RefSeq, Mar 2009].

Celluar localization

Cell membrane

UniPort

P11215