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Rabbit Anti-MORG1 Polyclonal Antibody#abs132742

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Description

Catalog-specification	Delivery time	USD price
abs132742-100ug	1-2 Weeks	301.0
abs132742-50ug	1-2 Weeks	201.0

Overview
catalog	abs132742
Description	This molecular scaffold protein is responsible for assembling various multimeric protein complexes. It plays a crucial role in the ERK pathway by linking specific agonists to ERK responses. Interestingly, it has a dual effect on ERK activation depending on its concentration. At low concentrations, it enhances ERK activation, whereas at high concentrations, it inhibits ERK activation. Besides its involvement in the ERK pathway, it also participates in the cellular response to hypoxia. Here, it acts as a negative regulator of HIF1A, also known as HIF-1-alpha, through its interaction with EGLN3, also known as PHD3. It aids in the degradation of HIF1A, potentially influencing cellular responses to hypoxia. Furthermore, this protein may play a role in pre-mRNA splicing. It could recruit signaling complexes to specific upstream activators, facilitating their function. In summary, this versatile protein fulfills multiple roles in various signaling pathways, contributing to the precise regulation of cellular processes.
Other names	WD repeat domain-containing protein 83, also known as MAPK organizer 1 or MGC4238, is an essential protein involved in organizing the mitogen-activated protein kinase (MAPK) pathway. It acts as a mediator between MAPKs and their downstream targets, enabling signal transduction and cellular responses to various stimuli. The protein, encoded by the MORG1 gene in humans, is characterized by its WD repeat domains, which are involved in protein-protein interactions. These repeats provide a structural framework for assembling multi-protein complexes involved in MAPK signaling cascades. MORG1 plays a crucial role in many cellular processes, including cell growth, proliferation, differentiation, and apoptosis. It acts as a scaffold protein, bringing together MAPKs, their upstream kinases, and downstream substrates, facilitating their interactions and regulating their activities. Mutations or dysregulation of MORG1 can have significant implications for cellular homeostasis and contribute to the development of various diseases, including cancer and neurological disorders. Therefore, studying the function and regulation of MORG1 is essential for understanding cellular signaling pathways and potentially identifying novel therapeutic targets. In conclusion, MORG1, also known as WD repeat domain-containing protein 83, is a vital component of the MAPK pathway that orchestrates signal transduction and cellular responses. Its involvement in multiple cellular processes underscores its significance in normal physiology and disease pathology. Further research is needed to unravel the precise mechanisms by which MORG1 regulates MAPK signaling and its potential therapeutic implications.
Source	Rabbit
Specificity	The MORG1 antibody is capable of detecting the total levels of endogenous MORG1 protein. To reiterate, this antibody is specifically designed to identify and measure the overall amount of MORG1 present in biological samples.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Dog;
Antigen	MORG1
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	34 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.
Celluar localization	Endosome;Nucleus;
UniPort	Q9BRX9