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Rabbit Anti-MDS1 Polyclonal Antibody#abs136964

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Description

Catalog-specification	Delivery time	USD price
abs136964-100ug	1-2 Weeks	301.0
abs136964-50ug	1-2 Weeks	201.0

Overview
catalog	abs136964
Description	This specific gene is responsible for encoding a transcriptional regulator and oncoprotein that plays a crucial role in various biological processes such as hematopoiesis, differentiation, proliferation, apoptosis, and development. It has the capability to interact with a range of proteins like CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. Multiple variants of this gene are present that encode different isoforms. The translocation of this gene with the AML1 gene results in overexpression leading to leukemia.
Other names	The AML1 EVI 1 fusion protein, also known as AML1 EVI1 or EVI1, is a key player in the development of certain diseases such as myelodysplasia syndrome. It is encoded by the MDS1 and EVI1 complex locus gene, also known as PRDM3. The protein is involved in regulating gene expression and plays a role in various cellular processes. The Ecotropic viral integration site 1 (EVI1) protein is a homolog of the Ecotropic virus integration site 1 protein. It is also referred to as MDS1, MDS1 EVI1, or the Myelodysplasia syndrome-associated protein 1. The MDS1 and EVI1 complex locus protein MDS1 is closely associated with EVI1 and together they form a complex that affects gene regulation. The significance of EVI1 in oncogenesis has been widely studied, as it is considered an oncogene. It is known to be involved in the development of certain cancers and is associated with poor prognosis. The Zinc finger protein Evi1, also known as MGC163392 or MGC97004, refers to a specific isoform of the EVI1 protein. Overall, the AML1 EVI 1 fusion protein and its associated proteins play crucial roles in normal cellular processes as well as disease development. By understanding their functions and mechanisms, researchers hope to develop novel therapeutic strategies targeted towards these proteins.
Source	Rabbit
Specificity	The MDS1 Antibody is designed to specifically target and recognize the natural levels of total MDS1 protein present within a biological sample.
Species Reactivity	Human;Mouse;Rat
Antigen	MDS1
Application	The dilutions for Western Blot (WB) range from 1:500 to 1:2000, for Immunohistochemistry (IHC) they range from 1:50 to 1:200, and for ELISA (peptide) they range from 1:20000 to 1:40000. It is important to accurately dilute the samples to ensure accurate and reliable results in these experiments. The dilution range mentioned is based on the optimal concentrations determined through previous experimentation and may vary depending on the specific antibody and antigen being used.
Immunogen	A synthesized peptide derived from human MECOM.
MW	118kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 Â°C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 Â°C.Stable for 12 months from date of receipt.
Target
Background	Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.
Posttranslational modification	Phosphorylated.May be acetylated by CREBBP and KAT2B.
Celluar localization	Cytosol;Nucleus;
UniPort	Q03112