Phospho-Stathmin1 (Ser15) Rabbit Polyclonal Antibody#abs130820

abs130820-50ug

1-2 Weeks

201

abs130820-100ug

1-2 Weeks

301

Description

The stathmin gene family includes this particular gene, which produces a cytosolic phosphoprotein found in virtually all cells. Its role is thought to involve acting as a mediator between various environmental signals that control cellular activity.

Other names

C1orf215, also known as Lag, LAP18, or Leukemia associated phosphoprotein p18, is a protein that has been linked to leukemia and tumor growth. It is also known as Oncoprotein 18 or OP18. Another closely related protein is Phosphoprotein 19 or p19, also referred to as pp17 or pp19. Another important protein is Pr22 or Prosolin, which is also known as Protein Pr22 and is involved in the regulation of cell growth and differentiation. Additionally, Stathmin or Stathmin1, which is also called STMN1 or Stmn1, plays a critical role in mitosis and the organization of the microtubule cytoskeleton. Understanding the functions of these proteins can provide valuable insights into the development and treatment of cancer and other diseases.

Source

Rabbit

Specificity

The Phospho-Stathmin 1 (Ser15) Antibody is designed to recognize and detect Stathmin 1 protein only when it is phosphorylated at Serine 15. This antibody can be used to study various biological processes that involve Stathmin 1 and its phosphorylation state. Detection of endogenous levels of Stathmin 1 phosphorylated at Serine 15 is possible with this antibody, which allows for precise and accurate analysis of protein expression and signaling pathways. Researchers can use this antibody to gain a better understanding of the role of Stathmin 1 in a wide range of biological processes, making it a valuable tool in scientific investigations.

Predictive reaction species

Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;

Application

IHC 1:50-1:200, WB 1:500-1:2000, IF/ICC 1:100-1:500, and ELISA(peptide) 1:20000-1:40000 are the recommended dilution ranges for various laboratory techniques. These dilutions are based on the original text information and can be followed to ensure accurate and reliable results in experiments.

A peptide that has been synthesized from human Stathmin 1 and focuses specifically on the phosphorylation site of Serine 15 is now available. This newly-developed peptide is highly similar to the original protein and is expected to offer numerous applications for researchers. With its unique formulation and optimized design, this peptide is set to revolutionize studies related to human Stathmin 1 and its role in various physiological processes. If you're looking for a top-quality peptide that accurately reflects the biochemical characteristics of the original protein, be sure to check out this newly released synthesized peptide today!

Properties

1mg/ml

Purification

The affinity-purified antibody was obtained from rabbit serum that had been purified through sequential chromatography on both phospho- and non-phospho-peptide affinity columns. This process ensured a high level of specificity for the targeted antigens and produced a highly purified and concentrated antibody, which is essential for its effective use as a research tool. This approach represents a common and reliable method for generating high-quality, specific antibodies for use in a variety of applications.

Clonality

Polyclonal Antibody

To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting the product to repeated cycles of freezing and thawing.

Storage buffer

The storage condition for Rabbit IgG is at -20 °C in phosphate-buffered saline (pH 7.4) containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This stable storage is guaranteed for a period of 12 months from the date of receipt.

Target

Background

This protein plays a crucial role in regulating the microtubule filament system by causing the destabilization of microtubules. Its primary function is to prevent the assembly and promote the disassembly of microtubules. In addition, phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Studies have also shown its involvement in controlling both learned and innate fear.

Tissue specificity

Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

Celluar localization

Cytoskeleton;Cytosol;Extracellular region or secreted;

P16949