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Rabbit Anti-CD74 Polyclonal Antibody#abs136961

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. We recommend contacting Vecent for accurate pricing details. Western blot analysis of extracts of various celllines, using CD74 antibody. This...

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Description

Catalog-specification	Delivery time	USD price
abs136961-100ug	1-2 Weeks	301.0
abs136961-50ug	1-2 Weeks	201.0

Overview
catalog	abs136961
Description	This gene encodes a crucial protein that plays a key role in the immune response by associating with class II major histocompatibility complex (MHC) and regulating antigen presentation. Acting as an important chaperone, this protein ensures efficient immune response activation. Additionally, it acts as a cell surface receptor for macrophage migration inhibitory factor (MIF), a cytokine that promotes cell survival and proliferation when bound to the encoded protein. Moreover, this versatile protein also interacts with amyloid precursor protein (APP) and exerts a suppressive effect on the production of amyloid beta (Abeta). Interestingly, multiple alternative forms of this gene have been identified, leading to the presence of different isoforms.
Other names	The CD74 antigen, also known as the invariant polypeptide of major histocompatibility complex, class II antigen-associated, is a molecule involved in the immune response. It is also referred to as the CD74 molecule, major histocompatibility complex, class II invariant chain, or CLIP. Other names include DHLAG, gamma chain of class II antigens, HG2A_HUMAN, HLA class II histocompatibility antigen gamma chain, HLA DR antigens associated invariant chain, HLA DR gamma, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, HLADG, HLADR antigens associated invariant chain, Ia antigen associated invariant chain, Ia antigen-associated invariant chain, Ia associated invariant chain, Ia gamma, Ii, Invariant polypeptide of major histocompatibility complex class II antigen associated, la-gamma, Major histocompatibility complex class II invariant chain, MHC HLA DR gamma chain, MHC HLA-DR gamma chain, p33, p35, and protein 41. To provide similar content while rearranging the above information, here is a revised version: The CD74 is a well-known antigen associated with the invariant polypeptide present in the major histocompatibility complex, particularly involved in class II antigen responses. Referred to as the CD74 molecule, it plays a significant role in immune system functions. Also known as CLIP, other names include DHLAG, gamma chain of class II antigens, HG2A_HUMAN, HLA class II histocompatibility antigen gamma chain, HLA DR antigens associated invariant chain, HLA DR gamma, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, HLADG, HLADR antigens associated invariant chain, Ia antigen associated invariant chain, Ia antigen-associated invariant chain, Ia associated invariant chain, Ia gamma, Ii, invariant polypeptide of major histocompatibility complex class II antigen associated, la-gamma, major histocompatibility complex class II invariant chain, MHC HLA DR gamma chain, MHC HLA-DR gamma chain, p33, p35, and protein 41.
Source	Rabbit
Specificity	The CD74 Antibody is capable of detecting total CD74 levels naturally present in the body. To create new content that is closely related to the original text, we can rearrange the information to say: Total CD74 levels in the body can be identified using the CD74 Antibody, which is specifically designed to detect this protein.
Species Reactivity	Human;Rat
Antigen	CD74
Application	Here are some variations: - For Western blotting, dilutions of 1:500 to 1:2000 are recommended, while for immunohistochemistry, dilutions of 1:50 to 1:200 are appropriate. When using ELISA with a peptide, dilute at 1:20000 to 1:40000. - To achieve optimal results, use dilutions of 1:500-1:2000 for Western blotting, 1:50-1:200 for immunohistochemistry, and 1:20000-1:40000 for ELISA with a peptide substrate. - When performing Western blotting, we advise using dilutions of 1:500-1:2000, while for immunohistochemistry, dilutions of 1:50-1:200 are recommended. To optimize detection with ELISA using a peptide, dilutions of 1:20000-1:40000 are suggested.
Immunogen	A synthesized peptide derived from human CD74.
MW	33kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLinkâ„¢ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 Â°C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 Â°C.Stable for 12 months from date of receipt.
Target
Background	Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
Posttranslational modification	N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
Celluar localization	Endoplasmic reticulum;Endosome;Extracellular region or secreted;Golgi apparatus;Lysosome;Plasma Membrane;
UniPort	P04233