Rabbit Anti-LEPR Polyclonal Antibody#abs136659
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Description
| Catalog-specification | Delivery time | USD price |
abs136659-100ug | 1-2 Weeks | 301.0 |
abs136659-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided is for reference purposes only. For more detailed pricing information, we advise you to contact our seller, Vecent. It is important to note that the content generated should be based on the original text, but rearranged and reworded in a highly similar manner to avoid plagiarism. As an AI language model, I am able to generate text that is significantly different from the original while still conveying the intended message.
| Overview | |
catalog | abs136659 |
Description | This gene codes for a protein that is a member of the gp130 cytokine receptor family, which mediates gene transcription by activating intracellular STAT proteins. Its primary function is to act as a receptor for leptin, a hormone produced by adipocytes that regulates body weight and fat metabolism. In addition, this protein is involved in a unique hematopoietic pathway that is essential for normal lymphopoiesis. Mutations in this gene have been linked to obesity and disorders of the pituitary gland. Interestingly, the gene shares the same promoter and first two exons as LEPROT, but the two genes produce distinct proteins. Various isoforms of this gene have been identified through alternative splicing. |
| Other names | The CD295 antigen, also known as CD295 or huB219, is a receptor protein called Leptin receptor (LEPR) found in humans. It is encoded by the LEPR gene and is present as a precursor in the body. LEPR is also referred to as LEP-R, LEPRD, or Leptin receptor fatty in certain contexts. Another name for LEPR is OB receptor (OB-R). It is associated with a gene-related protein called OB-RGRP. This protein plays a role in the binding and signaling of the hormone leptin, which regulates body weight and metabolism. |
| Source | Rabbit |
| Specificity | Total LEPR can be detected at endogenous levels with the use of LEPR Antibody. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | LEPR |
| Application | For Western blot, the recommended dilution range is 1:500–1:1000. Immunohistochemistry requires a dilution range of 1:50-1:100. If you're performing ELISA with a peptide, a concentration range of 1:20000-1:40000 is recommended. |
| Immunogen | A synthetic peptide of human LEPR. |
| MW | 96kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity). |
| Tissue specificity | Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus, but also in skeletal muscle. Detected in fundic and antral epithelial cells of the gastric mucosa (PubMed:19159218). Isoform B and isoform A are expressed by NK cells (at protein level) (PubMed:12504075). |
| Posttranslational modification | On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation. Phosphorylation of Tyr-1079 has a more accessory role. |
| Celluar localization | Extracellular region or secreted;Plasma Membrane; |
| UniPort | P48357 |
Western blot analysis of extracts of various celllines, using LEPR antibody.(1: HT-29 cell lysate2: K562 cell lysate)|Immunohistochemistryof paraffin-embeddedHuman colon cancer tissue usingLEPRantibody.
This product is for research use only, not for use in diagnostic prodecures or in human.
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