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Rabbit Anti-ITGA2 Polyclonal Antibody#abs132919

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Description

Catalog-specification	Delivery time	USD price
abs132919-50ug	1-2 Weeks	201.0
abs132919-100ug	1-2 Weeks	301.0

Overview
catalog	abs132919
Description	The cell receptor integrin alpha-2/beta-1 plays a crucial role in recognizing different extracellular matrix components, including laminin, collagen, collagen C-propeptides, fibronectin, and E-cadherin. It specifically recognizes a proline-hydroxylated sequence in collagen known as G-F-P-G-E-R. This receptor is involved in various vital functions, such as platelet and cell adhesion to collagens, modulation of collagen and collagenase gene expression, force generation, and organization of newly synthesized extracellular matrix.
Other names	CD49b, also known as Integrin alpha 2 or VLA-2 subunit alpha, is a glycoprotein found on the surface of platelets and some immune cells. It plays a crucial role in platelet adhesion and aggregation by binding to collagen in damaged blood vessels. Deficiencies in CD49b, also known as GP Ia deficiency or HPA 5 included, can result in a bleeding disorder. CD49b is also associated with the Platelet glycoprotein Ia/IIa and the Platelet membrane glycoprotein Ia. It is important to note that generating content based on language models should be done in a different way than content generated by ChapGPT, to ensure that the information conveyed is accurate and reliable.
Source	Rabbit
Specificity	The ITGA2 antibody is capable of identifying total ITGA2 levels present within the body. This is achieved by identifying the endogenous levels of ITGA2, specifically.
Species Reactivity	Human;Rat
Antigen	ITGA2
Application	For Western blotting, dilutions of 1:500-1:2000 can be effective. As for immunohistochemistry, a range of 1:50-1:200 is recommended. When it comes to ELISA testing with peptides, the dilution range should be set at 1:20000-1:40000. It is important to note that adjusting the dilution can impact the quality of results obtained. Always perform careful experimentation to ensure optimal assay conditions.
Immunogen	A synthesized peptide.
MW	150 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
Celluar localization	Nucleus;Plasma Membrane;
UniPort	P17301