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Phospho-14-3-3 Delta (Ser186) Rabbit Polyclonal Antibody#abs140287

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Description

Catalog-specification	Delivery time	USD price
abs140287-100ug	1-2 Weeks	301.0
abs140287-50ug	1-2 Weeks	201.0

Overview
catalog	abs140287
Other names	The 14-3-3 protein sigma, also known as SFN or stratifin, is an epithelial cell marker protein 1 involved in various cellular processes such as cell cycle control, signal transduction, and apoptosis. It is encoded by the Mkrn3 gene and also known as Mme1. The protein is expressed in several tissues, including in the human mammary gland as HME 1, and is involved in regulating the growth of cells. It is a member of the 14-3-3 family of proteins and has been suggested to have a role in carcinogenesis. Overall, the 14-3-3 protein sigma is an important protein with various roles in cell regulation and signaling.
Source	Rabbit
Specificity	The antibody 14-3-3σ (Phospho-Ser186) is specifically designed to recognize and bind to the endogenous levels of phosphorylated 14-3-3σ at Ser186.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	14-3-3 delta
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	14-3-3σ（186）。，。ChapGPT，。
MW	28kDa
Properties
Concentration	1mg/ml
purification	The purified rabbit serum has been used for the generation of the antibody through affinity purification, which involved sequential chromatography on both phospho- and non-phospho-peptide affinity columns. The resulting antibody has a high similarity to the original serum and can be used for various applications. This method of purification ensures that the antibody is specific to the desired target and has minimal cross-reactivity. The use of affinity columns ensures that the antibody is highly pure and does not contain any unwanted contaminants.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the freshness, store at a temperature of -20 °C for a period of one year. It is crucial to prevent any freeze/thaw cycles from occurring repeatedly.
Storage buffer	This rabbit IgG solution is formulated in a phosphate buffered saline with pH 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. For optimal stability, it should be stored at -20°C and kept from light. The solution is stable for a minimum of 12 months from the date of receipt.
Target
Background	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
Tissue specificity	Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Posttranslational modification	Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.
Celluar localization	Cytosol;Extracellular region or secreted;Mitochondrion;Nucleus;
UniPort	P31947

Western blot analysis 14-3-3σ (Phospho-Ser186) using EGF treated HepG2 whole cell lysates

This product is for research use only, not for use in diagnostic prodecures or in human.

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