Rabbit Anti-FSHR Polyclonal Antibody#abs131337
Please note that the price mentioned above is for your reference only. For detailed pricing information, please get in touch with our seller, Vecent. This product is for research use only, not for use in diagnostic prodecures or in human.
Description
| Catalog-specification | Delivery time | USD price |
abs131337-50ug | 1-2 Weeks | 201.0 |
abs131337-100ug | 1-2 Weeks | 301.0 |
Please note that the price mentioned above is for your reference only. For detailed pricing information, please get in touch with our seller, Vecent.
| Overview | |
catalog | abs131337 |
Description | The FSH receptor is responsible for the stimulation of follicle growth and development. This receptor utilizes G proteins to activate adenylate cyclase and regulate its activity. |
| Other names | The receptor for follicle stimulating hormone, known as the follicle stimulating hormone receptor, comes in multiple isoforms, with isoform 1 being the most common. This receptor, also referred to as FSH-R or FSHR, is involved in the biological responses to follicle stimulating hormone. Other names for this receptor include follitropin receptor, FSHRO, LGR1, and ODG1. It is also encoded by genes such as FSHR_HUMAN, Fshr, MGC141667, and MGC141668. Mutations in this receptor have been associated with ovarian dysgenesis 1, a condition characterized by improper development of the ovaries. |
| Source | Rabbit |
| Specificity | The total amount of FSHR can be detected using the FSHR Antibody, which is able to identify the endogenous levels of this protein. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Rabbit;Pig;Sheep;Horse;Bovine |
| Antigen | FSHR |
| Application | The recommended dilutions for using the antibody in various applications are as follows: 1:500-1:2000 for western blotting, 1:50-1:200 for immunohistochemistry, 1:100-1:500 for immunofluorescence/immunocytochemistry, and 1:20000-1:40000 for ELISA using peptide as antigen. It is important to use the correct dilution for each application to ensure optimal results. The antibody has been tested and validated in these applications and dilution ranges, but optimal conditions may vary for different sample types and experimental setups. It is recommended to perform a titration experiment to determine the optimal dilution for each individual experiment. |
| Immunogen | A synthesized peptide derived from human FSHR. |
| MW | 78 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To maintain quality, it is recommended to store at a temperature of -20 °C for a period of one year. It is important to prevent frequent freezing and thawing cycles. |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Receptor for follicle-stimulating hormone or follitropin (PubMed:11847099, PubMed:24058690). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways (PubMed:24058690). |
| Tissue specificity | Sertoli cells and ovarian granulosa cells. |
| Posttranslational modification | Sulfated.N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone. |
| Celluar localization | Plasma Membrane; |
| UniPort | P23945 |
This product is for research use only, not for use in diagnostic prodecures or in human.
Hot Tags: rabbit anti-fshr polyclonal antibody#abs131337, China rabbit anti-fshr polyclonal antibody#abs131337 suppliers
Send Inquiry
You Might Also Like
