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Phospho-ILK-1 (Ser343) Rabbit Polyclonal Antibody#abs139899

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Description

Catalog-specification	Delivery time	USD price
abs139899-100ug	1-2 Weeks	301.0
abs139899-50ug	1-2 Weeks	201.0

Overview
catalog	abs139899
Other names	This protein is known as a 59 kDa serine/threonine protein kinase, which is alternatively referred to as DKFZp686F1765, Epididymis Secretory Protein Li 28, HEL S 28, ILK1, ILK2, ILK, ILK-1, ILK-2, ILK_HUMAN, ILK1, ILK2, Integrin Linked Kinase 2, Integrin Linked Kinase, Integrin Linked Protein Kinase, Integrin-Linked Protein Kinase, p59, and p59ILK. It plays a crucial role in the regulation of cellular processes, such as cell adhesion, migration, proliferation, differentiation, and survival, through its interaction with integrin receptors and cytoskeletal and signaling molecules. This protein kinase is widely expressed in various tissues, including skeletal muscle, heart, lung, kidney, brain, and cancer cells, and its dysregulation is implicated in several diseases, such as cancer, muscular dystrophy, cardiovascular disorders, and neurodegenerative disorders. Further research on this protein is required to elucidate its full molecular mechanism and potential as a therapeutic target.
Source	Rabbit
Specificity	The ILK-1 (Phospho-Ser343) Antibody is specifically designed to recognize and bind to ILK-1 protein, but only when it is phosphorylated at Ser343. It is capable of detecting the endogenous levels of ILK-1 in a sample, indicating the presence of ILK-1 protein phosphorylated at Ser343. By targeting this specific phosphorylation site, the antibody provides valuable information about the activation status of ILK-1.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	ILK-1
Application	The dilution ranges for WB (western blot) are 1:1000-3000, for IHC (immunohistochemistry) are 1:50-1:200, and for ELISA (enzyme-linked immunosorbent assay) using peptides are 1:20000-1:40000.
Immunogen	ILK-1 (Phospho-Ser343), a human-derived peptide, has been synthesized to create a highly similar content. This peptide is generated using the original information on human ILK-1.
MW	51.4kDa
Properties
Concentration	1mg/ml
purification	，。，。
Clonality	Polyclonal Antibody
Stability & Storage	To ensure maximum efficacy, it is recommended to store the product at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing, as this may compromise its quality and effectiveness. Take care to follow these guidelines to maintain the product's integrity.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715).
Tissue specificity	Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
Posttranslational modification	Autophosphorylated on serine residues.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;Plasma Membrane;
UniPort	Q13418