Rabbit Anti-Interleukin 12A Polyclonal Antibody#abs131211

abs131211-50ug

1-2 Weeks

201

abs131211-100ug

1-2 Weeks

301

Description

This cytokine is known for its ability to function as a growth factor for activated T and NK cells. Additionally, it can enhance the lytic activity of NK/lymphokine-activated Killer cells and stimulate the production of IFN-gamma by resting PBMC. This makes it an essential component in the immune system's response to various stimuli. Its unique properties enable it to play a critical role in fighting infections and diseases. As one of the most important cytokines in the body, it helps to regulate the immune response and increase the efficiency and effectiveness of immune cells. This makes it a valuable target for future research and development of therapeutic treatments.

Other names

Interleukin 12A, also known as Cytotoxic Lymphocyte Maturation Factor 1 p35 or CLMF p35, is a subunit of the cytokine IL-12. It plays a crucial role in regulating immune responses by promoting the differentiation of T cells and natural killer cells. IL-12 subunit p35 is also involved in the activation of cytokine production and the stimulation of cytotoxic activity in these cells. Additionally, IL-12 subunit p35 has been shown to have potential therapeutic applications in various diseases, such as cancer and infectious diseases. Other names for IL-12 subunit p35 include Interleukin 12 p35, NK Cell Stimulatory Factor Chain 1, and Natural Killer Cell Stimulatory Factor 1 35 kD Subunit. Its structure and function are essential for the proper functioning of the immune system and the maintenance of overall health.

Source

Rabbit

Specificity

The antibody against Interleukin 12A is capable of detecting the total amount of the protein that naturally occurs within a sample. This means that the antibody has the ability to recognize and bind to endogenous levels of Interleukin 12A, enabling accurate analysis of its presence and quantity.

Predictive reaction species

Pig;Rabbit;Sheep;Dog;Bovine;Horse;

Application

The dilutions for Western blot (WB) range from 1:500 to 1:2000, for immunohistochemistry (IHC) range from 1:50 to 1:200, and for ELISA (peptide) range from 1:20000 to 1:40000. Please note that the dilution values mentioned above are based on the original information provided.

A newly created peptide was developed from human Interleukin 12A. This peptide is highly similar to the original form, as it was synthesized based on the existing content. With this breakthrough, researchers hope to use the peptide for various applications, such as in medical treatments or research studies. The development of this peptide may also open up new possibilities for drug development and molecular biology research. Overall, this is an exciting development in the field of biochemistry and could have significant implications for future studies.

Properties

1mg/ml

Purification

SulfoLink™ Coupling Resin was used for peptide affinity chromatography to purify the antiserum. Similarly, a highly similar content could read: Using SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum.

Clonality

Polyclonal Antibody

To maintain the quality of the product, we recommend storing it at a temperature of -20 °C for up to one year. It's important to avoid any unnecessary freeze/thaw cycles to prevent any damage or alteration to the product. Please keep this in mind as you handle and store the product accordingly.

Storage buffer

This product contains Rabbit IgG in phosphate buffered saline at a pH of 7.4 with 150mM NaCl, 0.02% sodium azide and 50% glycerol. It is recommended to store this item at a temperature of -20 °C for optimal preservation. This product is stable for up to 12 months from the date of purchase.

Target

Background

 Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.

Tissue specificity

Down-regulated in response to enterovirus 71 (EV71) infection.

Celluar localization

P29459