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Rabbit Anti-InsP5 2-kinase Polyclonal Antibody#abs140451

Description

Catalog-specification	Delivery time	USD price
abs140451-100ug	1-2 Weeks	301.0
abs140451-50ug	1-2 Weeks	201.0

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Overview
catalog	abs140451
Other names	Here are some possible rearrangements of the provided content: 1. Inositol-1,3,4,5,6 pentakisphosphate 2 kinase, also known as InsP5 2 kinase or IPK1, is an enzyme that catalyzes the phosphorylation of inositol pentakisphosphate (InsP5) to generate 6-phosphorylated InsP5. This reaction requires ATP as a phosphate donor and plays a role in the regulation of cellular signaling and metabolism. The human gene encoding this enzyme is called INSP5K2 or IPPK and is located on chromosome 9 (C9orf12). A homolog of IPK1 has been identified in other organisms, such as yeast and plants. 2. IP5K, or inositol pentakisphosphate 2 kinase, is a protein that belongs to the family of kinases that phosphorylate inositol phosphates. Specifically, IP5K phosphorylates Ins(1,3,4,5,6)P5 to generate InsP6, also known as inositol hexakisphosphate. This reaction is important for the regulation of cellular signaling and homeostasis. IP5K has also been implicated in the pathogenesis of certain diseases, such as cancer and diabetes. The human gene for IP5K is located on chromosome 9 and is called INSP5K2 or IPPK. 3. bA476B13.1, a novel protein of unknown function, has been identified in humans and is encoded by the C9orf12 gene on chromosome 9. The protein contains a conserved domain that is found in several other proteins, including IP5K, and has been suggested to be involved in inositol phosphate metabolism. Further research is needed to elucidate the precise role of bA476B13.1 in cellular physiology. 4. Inositol-1,3,4,5,6 pentakisphosphate 2 kinase (IPP2K) is an enzyme that phosphorylates Ins(1,3,4,5,6)P5 to generate 2-phosphorylated InsP5. This reaction is important for the regulation of cellular signaling and metabolism and has been implicated in various physiological processes, such as insulin secretion and neuronal activity. In humans, IPP2K is encoded by the INSP5K2 or IPPK gene on chromosome 9 and shares high sequence similarity with other inositol phosphate kinases, such as IP5K and IPMK.
Source	Rabbit
Specificity	The total InsP5 2-kinase can be accurately detected using the InsP5 2-kinase Antibody, allowing for the measurement of endogenous levels.
Species Reactivity	Human;Mouse
Predictive reaction species	Sheep;Bovine;Rabbit;Pig;
Antigen	InsP5 2-kinase
Application	For Western Blotting, the recommended dilution ratio is 1:1000. As for Immunohistochemistry, the suggested dilution ratio is 1:200. For ELISA using a peptide substrate, the dilution ratio ranges from 1:20000 to 1:40000. These dilution ratios are based on the original text information and can help ensure accurate and efficient results in laboratory experiments.
Immunogen	Human InsP5 2-kinase is the source for a synthetic peptide I am about to discuss. This peptide has been derived from the mentioned kinase. To provide you with a similar but rearranged content, let me introduce the peptide originating from human InsP5 2-kinase.
MW	56kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure maximum shelf life, it is recommended that the product be stored at a temperature of -20 °C for a period of one year. However, it is important to avoid subjecting the product to repeated freeze/thaw cycles, as this can negatively impact its quality and overall effectiveness. By following these guidelines carefully, you can help ensure that the product remains in optimal condition and retains its full efficacy over an extended period of time.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.
Tissue specificity	Ubiquitously expressed, with high expression in heart, brain, testis and placenta.
Celluar localization	Cytosol;Nucleus;
UniPort	Q9H8X2