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Rabbit Anti-INGR2 Polyclonal Antibody#abs138508

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Description

Catalog-specification	Delivery time	USD price
abs138508-100ug	1-2 Weeks	301.0
abs138508-50ug	1-2 Weeks	201.0

Overview
catalog	abs138508
Other names	The Interferon Gamma Receptor 2, also known as AF-1, AF1, IFGR2, IFNGR2, or IFNGT1, is an essential component of the immune system. It is responsible for activating various immune cells, such as macrophages and natural killer cells, to fight off infections and tumors. This receptor is made up of several chains, including the beta chain and chain 2. It works in conjunction with Interferon Gamma Transducer 1, or IMD28, to transmit signals from interferon gamma, a cytokine that plays a critical role in mediating the immune response. Additionally, the Interferon Gamma Receptor Accessory Factor 1 supports the function of this receptor. The IFN-gamma receptor 2, also known as IFN-gamma-R2, IFNGR2, or IFNGT1, is a crucial protein involved in the immune response. This receptor comprises various chains, including the beta chain and chain 2, and works alongside Interferon Gamma Transducer 1 or IMD28, to transmit signals from interferon gamma, a cytokine that plays a significant role in activating various immune cells like macrophages and natural killer cells to fight off infections or cancers. Furthermore, the Interferon Gamma Receptor Accessory Factor 1 is responsible for aiding the function of this critical receptor in the immune system.
Source	Rabbit
Specificity	The total INGR2 levels in the body can be accurately detected using the INGR2 Antibody, which specifically targets and recognizes the endogenous INGR2 proteins.
Species Reactivity	Human
Antigen	INGR2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human INGR2.
MW	38 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we purified the antiserum through peptide affinity chromatography. This process allowed us to separate and isolate specific peptides in order to create a purified form of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	It is advised to store at a temperature of -20 °C for a duration of one year. To maintain the quality, it is important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	The rabbit IgG is dissolved in a solution of phosphate buffered saline with a pH of 7.4, containing 150 millimoles of NaCl, 0.02% of sodium azide, and 50% glycerol. It is recommended to keep the solution frozen at -20°C and is stable for approximately 12 months from when it was first received.
Target
Background	Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114,PubMed:7615558). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114).
Tissue specificity	Expressed in T-cells (at protein level).
Celluar localization	Endoplasmic reticulum;Golgi apparatus;Plasma Membrane;
UniPort	P38484