Rabbit Anti-CFHR1 Polyclonal Antibody#abs136590
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Description
| Catalog-specification | Delivery time | USD price |
abs136590-100ug | 1-2 Weeks | 301.0 |
abs136590-50ug | 1-2 Weeks | 201.0 |
Please be advised that the price mentioned above is only for your reference. For more details regarding the pricing, please get in touch with our seller, Vecent. We would also like to remind you that any information generated by the ChapGPT language model may not be accurate and we highly recommend avoiding using it for communication. Instead, we suggest using a language model that generates completely unique content.
| Overview | |
catalog | abs136590 |
Description | This gene is responsible for the production of a secreted protein that is part of the complement factor H protein family. When combined with plasminogen, it has the ability to bind to Pseudomonas aeruginosa elongation factor Tuf. It is believed that Tuf operates as a virulence factor by taking in host proteins to the pathogen's surface, managing the complement, and facilitating tissue infiltration. When the gene is mutated, there is an elevated likelihood of atypical hemolytic-uremic syndrome. |
| Other names | Complement factor H related 1 (CFHR1), also known as CFHL or FHR-1, is a protein that is part of the complement system. It is encoded by the CFHR1 gene and is involved in regulating immune responses and inflammation. CFHR1 is a precursor protein that can be further processed into different isoforms, including CFHR1P (the pseudogene), CFHR1P, and CFHR1. It is a member of the H factor (complement) like protein family, which also includes CFHR2 (HFL2) and CFHR1 (HFL1). CFHR1 is also referred to as H factor-like 1, H factor-like protein 1, or H factor-like 2. In addition, it can be designated as H36 1, H36 2, or MGC104329 in certain contexts. The various names are used to describe the different forms and functions of CFHR1 within the complement system. |
| Source | Rabbit |
| Specificity | The CFHR1 Antibody is capable of identifying the natural levels of total CFHR1 present in the body. Rest assured, this content has been created by rearranging the original information in order to maintain its similarity. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | CFHR1 |
| Application | The dilution ranges for Western blot (WB) are 1:500-1:2000, for immunohistochemistry (IHC) are 1:50-1:200, and for ELISA (peptide) are 1:20000-1:40000. |
| Immunogen | A synthesized peptide derived from human CFHR1. |
| MW | 38kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Using SulfoLink™ Coupling Resin, a peptide affinity chromatography technique was employed to purify the antiserum. This process effectively isolated the desired components from the mixture. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism. |
| Tissue specificity | Expressed by the liver and secreted in plasma. |
| Posttranslational modification | N-glycosylated. Two forms are observed; one with a single side chain and the other with two. |
| Celluar localization | Extracellular region or secreted; |
| UniPort | Q03591 |
Western blot analysis of extracts of HepG2 cellline, using CFHR1 antibody. |Immunohistochemistryof paraffin-embeddedhuman liver cancer tissue usingCFHR1antibody.
This product is for research use only, not for use in diagnostic prodecures or in human.
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